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cnd1 condensin complex non-SMC subunit Cnd1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2541201, updated on 11-Apr-2024

Summary

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Gene symbol
cnd1
Gene description
condensin complex non-SMC subunit Cnd1
Locus tag
SPBC776.13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (3200081..3203986)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L28 Neighboring gene Dbf4(Dfp1)-dependent protein kinase Hsk1 Neighboring gene phospholipid--diacylglycerol acyltransferase Plh1 Neighboring gene dihydrolipoyllysine-residue succinyltransferase Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1. Schiklenk C, et al. J Cell Biol, 2018 Jul 2. PMID 29735745, Free PMC Article
  2. RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast. Nakazawa N, et al. Genes Cells, 2015 Jun. PMID 25847133, Free PMC Article
  3. ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding. Akai Y, et al. Open Biol, 2014 Dec. PMID 25520186, Free PMC Article
  4. Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2. Nakazawa N, et al. J Cell Sci, 2011 Jun 1. PMID 21540296
  5. Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis. Nakazawa N, et al. J Cell Biol, 2008 Mar 24. PMID 18362178, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we identify the C2H2 zinc-finger transcription factor Zas1 as a key regulator of mitotic condensation dynamics in a quantitative live-cell microscopy screen of the fission yeast Schizosaccharomyces pombe By binding to specific DNA target sequences in their promoter regions, Zas1 controls expression of the Cnd1 subunit of the condensin protein complex and several other target genes
    Title: Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.
  2. Study reports isolation and characterization of 21 fission yeast mutants for three non-SMC subunits, created using error-prone mutagenesis that resulted in single-amino acid substitutions; Three cnd1 and three cnd3 mutants increased cell size and doubled DNA content, thereby eliminating the haploid state implicating Cnd1 and Cnd3 in ploidy maintenance.
    Title: Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA-DNA tethering activity EXP
Inferred from Experiment
more info
 PubMed 
enables double-stranded DNA binding EXP
Inferred from Experiment
more info
 PubMed 
contributes_to double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to topological DNA co-entrapment activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in condensed chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolar peripheral inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
condensin complex non-SMC subunit Cnd1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    3200081..3203986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022250.2 → NP_596329.1  condensin complex non-SMC subunit Cnd1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596329.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94679
    Conserved Domains (4) summary
    COG5098
    Location:9 → 1158
    COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
    pfam12717
    Location:974 → 1142
    Cnd1; non-SMC mitotic condensation complex subunit 1
    pfam12922
    Location:72 → 232
    Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
    sd00044
    Location:309 → 342
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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