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Cd80 Cd80 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 25408, updated on 17-Nov-2020

Summary

Symbol
Cd80provided by RGD
Full Name
Cd80 moleculeprovided by RGD
Primary source
RGD:2314
See related
Ensembl:ENSRNOG00000001527
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B7-1
Summary
cell surface protein that is part of the immune response; may be involved in induction of experimental autoimmune anterior uveitis [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 25.4), Thymus (RPKM 23.2) and 8 other tissues See more
Orthologs

Genomic context

See Cd80 in Genome Data Viewer
Location:
11q21
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64815201..64855293, complement)
106 current Rn_Celera (GCF_000002265.2) 11 AC_000079.1 (61768874..61793351, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (67255123..67291544)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39a Neighboring gene protein O-glucosyltransferase 1 Neighboring gene uncharacterized LOC103693581 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
protein complex involved in cell adhesion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-lymphocyte activation antigen CD80
Names
CD80 antigen
CD80-like
Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012926.1NP_037058.1  T-lymphocyte activation antigen CD80

    See identical proteins and their annotated locations for NP_037058.1

    Status: PROVISIONAL

    Source sequence(s)
    AF010465
    UniProtKB/TrEMBL
    O35187
    Related
    ENSRNOP00000002089.4, ENSRNOT00000002089.4
    Conserved Domains (3) summary
    smart00410
    Location:41143
    IG_like; Immunoglobulin like
    pfam08205
    Location:147232
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:43144
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    64815201..64855293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248365.3XP_006248427.1  T-lymphocyte activation antigen CD80 isoform X1

    See identical proteins and their annotated locations for XP_006248427.1

    UniProtKB/TrEMBL
    G3V671
    Conserved Domains (2) summary
    pfam08205
    Location:147232
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:43144
    Ig; Immunoglobulin domain
  2. XM_017597884.1XP_017453373.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    G3V671
    Conserved Domains (2) summary
    pfam08205
    Location:147232
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:43144
    Ig; Immunoglobulin domain
  3. XM_017597885.1XP_017453374.1  T-lymphocyte activation antigen CD80 isoform X1

    UniProtKB/TrEMBL
    G3V671
    Related
    ENSRNOP00000071419.1, ENSRNOT00000089625.1
    Conserved Domains (2) summary
    pfam08205
    Location:147232
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:43144
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    61768874..61793351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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