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tbf1 DNA-binding factor Trf1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540732, updated on 19-Nov-2025
Official Symbol
tbf1
Official Full Name
DNA-binding factor Trf1
Primary source
PomBase:SPBC19G7.13
Locus tag
SPOM_SPBC19G7.13
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
trf1
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See tbf1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (2373925..2376516)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COG complex subunit Cog5 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor. Wu Z, et al. Structure, 2024 Jul 11. PMID 38677290
  2. Identification and characterization of an essential telomeric repeat binding factor in fission yeast. Pitt CW, et al. J Biol Chem, 2008 Feb 1. PMID 17977837
  3. Functional differentiation of tbf1 orthologues in fission and budding yeasts. Cockell MM, et al. Eukaryot Cell, 2009 Feb. PMID 19074598, Free PMC Article
  4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
  5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
    Title: Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
  2. Fission and budding yeast Tbf1 proteins have diverged significantly in their functions.
    Title: Functional differentiation of tbf1 orthologues in fission and budding yeasts.
  3. Targeted deletion of the tbf1 gene reveals that it is essential for survival, and overexpression of the tbf1 gene leads to telomere elongation in vivo, which is dependent upon the MYB domain.
    Title: Identification and characterization of an essential telomeric repeat binding factor in fission yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via telomere lengthening IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, telomeric repeat region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding factor Trf1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2373925..2376516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021886.3 → NP_595979.1  DNA-binding factor Trf1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595979.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O42961, Q6E434, Q9US79
    Conserved Domains (3) summary
    smart00717
    Location:405 → 461
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11660
    Location:406 → 461
    SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
    pfam08558
    Location:98 → 319
    TRF; Telomere repeat binding factor (TRF)
Nucleotide Protein
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