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tor2 TORC1 serine/threonine protein kinase Tor2 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540720, updated on 18-Sep-2024

Summary

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Official Symbol
tor2
Official Full Name
TORC1 serine/threonine protein kinase Tor2
Primary source
PomBase:SPBC216.07c
Locus tag
SPOM_SPBC216.07C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
SPBC646.01c
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Genomic context

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See tor2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (915085..922352, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ATR checkpoint kinase Rad3 Neighboring gene replication fork protection complex subunit Swi1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Cwf11 Neighboring gene ncRNA Neighboring gene glutamyl-tRNA amidotransferase alpha subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The TOR-dependent phosphoproteome and regulation of cellular protein synthesis. Mak T, et al. EMBO J, 2021 Aug 16. PMID 34296454, Free PMC Article
  2. TORC1-Dependent Phosphorylation Targets in Fission Yeast. Otsubo Y, et al. Biomolecules, 2017 Jul 3. PMID 28671615, Free PMC Article
  3. TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation. Hirai H, et al. Cell Rep, 2023 Nov 28. PMID 37913773
  4. Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan. Shetty M, et al. Aging Cell, 2020 Feb. PMID 31833215, Free PMC Article
  5. Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Valbuena N, et al. J Cell Sci, 2012 Dec 15. PMID 23108671

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
    Title: TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
  2. Data indicate that AMP-activated protein kinase beta subunit Amk2 (Amk2) and glycogen synthase kinase 3 (Gsk3) act in parallel to inhibit TORC1 (Tor2) function.
    Title: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
  3. Since Gaf1 was also critical for transcription of per1+ and put4+, Tor-Gaf1 signaling may coordinate transcription of multiple amino acid permeases according to nutrient availability
    Title: Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.
  4. These results suggest that nitrogen depletion decreases Tor2 activity through Tsc2, thereby promoting the surface expression of Agp3 from trans-Golgi/endosomes.
    Title: Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast.
  5. Data show that the newly synthesized glucose transport Ght5 locates preferentially at the cell tips with the aid of the target of rapamycin (TOR) complex 2 signaling.
    Title: Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.
  6. While mutated TORC1 and TORC2 displayed diminished kinase activity and FKBP12/Fkh1-dependent rapamycin sensitivity, their phenotypes were nearly opposite in mitosis.
    Title: The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
  7. Rapamycin inactivates Tor2 activity in the presence of caffeine.
    Title: TORC1 of fission yeast is rapamycin-sensitive.
  8. The double mutant tor2-51 pka1Delta showed a faster rate of accumulation of cells with 1C DNA content, indicating that the TOR and the PKA pathways cooperate to prevent cell cycle exit and G1 arrest in fission yeast.
    Title: TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
  9. Rapamycin inhibits the ability of TORC1 to phosphorylate Rps6, owing to interaction of the rapamycin-FKBP12 complex with the FRB domain in Tor2
    Title: Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
  10. Studies postulate that the signaling cascade may branch below Rhb1 or Tor2 and regulate the amino acid uptake and response to nitrogen starvation independently.
    Title: Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA primary transcript binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle EXP
Inferred from Experiment
more info
 PubMed 
involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of induction of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation EXP
Inferred from Experiment
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TOR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Tor2-Mei2-Ste11 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
is_active_in nucleolar chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TORC1 serine/threonine protein kinase Tor2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    915085..922352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021266.4 → NP_595359.2  TORC1 serine/threonine protein kinase Tor2 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595359.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O94507, Q9Y7K2
    Conserved Domains (7) summary
    COG5032
    Location:194 → 2337
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05169
    Location:1955 → 2233
    PIKKc_TOR; Catalytic domain of Target of Rapamycin
    pfam02260
    Location:2307 → 2337
    FATC; FATC domain
    pfam08771
    Location:1817 → 1914
    Rapamycin_bind; Rapamycin binding domain
    pfam11865
    Location:722 → 880
    DUF3385; Domain of unknown function (DUF3385)
    pfam13513
    Location:662 → 715
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:565 → 592
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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