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Cd44 CD44 molecule (Indian blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25406, updated on 19-May-2022

Summary

Official Symbol
Cd44provided by RGD
Official Full Name
CD44 molecule (Indian blood group)provided by RGD
Primary source
RGD:2307
See related
Ensembl:ENSRNOG00000006094 AllianceGenome:RGD:2307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD44A; METAA; RHAMM
Summary
Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 333.2), Spleen (RPKM 283.1) and 8 other tissues See more
Orthologs
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Genomic context

See Cd44 in Genome Data Viewer
Location:
3q32
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89155850..89244615, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (92695083..92783820, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene solute carrier family 1 member 2 Neighboring gene uncharacterized LOC120101608 Neighboring gene uncharacterized LOC120101453 Neighboring gene similar to ribosomal protein S8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124941

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to cytokine binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel maturation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mature B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lamellipodium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within wound healing involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of macrophage migration inhibitory factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of macrophage migration inhibitory factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CD44 antigen
Names
Cell surface glycoprotein CD44 (hyaluronate binding protein)
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
PGP-1
PGP-I
extracellular matrix receptor III
hermes antigen
hyaluronate receptor
phagocytic glycoprotein 1
phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012924.3NP_037056.3  CD44 antigen precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000118
    Related
    ENSRNOP00000009000.3, ENSRNOT00000009000.8
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    89155850..89244615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762058.3XP_008760280.1  CD44 antigen isoform X11

    Related
    ENSRNOP00000096654.1, ENSRNOT00000107007.1
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  2. XM_039104361.1XP_038960289.1  CD44 antigen isoform X1

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  3. XM_039104362.1XP_038960290.1  CD44 antigen isoform X2

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  4. XM_039104363.1XP_038960291.1  CD44 antigen isoform X3

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  5. XM_039104364.1XP_038960292.1  CD44 antigen isoform X4

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  6. XM_039104366.1XP_038960294.1  CD44 antigen isoform X6

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  7. XM_006234627.4XP_006234689.1  CD44 antigen isoform X5

    Related
    ENSRNOP00000008760.7, ENSRNOT00000008760.8
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  8. XM_039104367.1XP_038960295.1  CD44 antigen isoform X7

    Related
    ENSRNOP00000090715.1, ENSRNOT00000111131.1
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  9. XM_039104368.1XP_038960296.1  CD44 antigen isoform X8

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  10. XM_006234629.4XP_006234691.1  CD44 antigen isoform X9

    Related
    ENSRNOP00000080825.1, ENSRNOT00000111172.1
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  11. XM_017591492.2XP_017446981.1  CD44 antigen isoform X10

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  12. XM_006234631.4XP_006234693.1  CD44 antigen isoform X13

    See identical proteins and their annotated locations for XP_006234693.1

    UniProtKB/Swiss-Prot
    P26051
    UniProtKB/TrEMBL
    O70509
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  13. XM_039104369.1XP_038960297.1  CD44 antigen isoform X12

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...