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Cd44 CD44 molecule (Indian blood group) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25406, updated on 9-Sep-2018

Summary

Official Symbol
Cd44provided by RGD
Official Full Name
CD44 molecule (Indian blood group)provided by RGD
Primary source
RGD:2307
See related
Ensembl:ENSRNOG00000006094
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD44A; METAA; RHAMM
Summary
adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 333.2), Spleen (RPKM 283.1) and 8 other tissues See more
Orthologs

Genomic context

See Cd44 in Genome Data Viewer
Location:
3q32
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (92695083..92783820, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (99338248..99426188, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene solute carrier family 1 member 2 Neighboring gene similar to ribosomal protein S8 Neighboring gene pyruvate dehydrogenase complex, component X

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC124941

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to cytokine binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
blood vessel maturation IEP
Inferred from Expression Pattern
more info
PubMed 
branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cartilage development ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hyaluronan catabolic process IEA
Inferred from Electronic Annotation
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
macrophage fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte aggregation IEA
Inferred from Electronic Annotation
more info
 
monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mature B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte aggregation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lamellipodium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of lamellipodium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin A IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage migration inhibitory factor receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage migration inhibitory factor receptor complex IEA
Inferred from Electronic Annotation
more info
 
macrophage migration inhibitory factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CD44 antigen
Names
CD44 antigen isoform d6-12
CD44 antigen isoform d6-13
CD44 antigen isoform d6-15
Cell surface glycoprotein CD44 (hyaluronate binding protein)
ECMR-III
GP90 lymphocyte homing/adhesion receptor
HUTCH-I
PGP-1
PGP-I
extracellular matrix receptor III
hermes antigen
hyaluronate receptor
phagocytic glycoprotein 1
phagocytic glycoprotein I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012924.2NP_037056.2  CD44 antigen precursor

    See identical proteins and their annotated locations for NP_037056.2

    Status: PROVISIONAL

    Source sequence(s)
    U96138
    UniProtKB/TrEMBL
    O08779
    Related
    ENSRNOP00000009000.3, ENSRNOT00000009000.7
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    92695083..92783820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234627.3XP_006234689.1  CD44 antigen isoform X1

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  2. XM_008762055.2XP_008760277.1  CD44 antigen isoform X2

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  3. XM_008762056.2XP_008760278.1  CD44 antigen isoform X3

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  4. XM_006234629.3XP_006234691.1  CD44 antigen isoform X4

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  5. XM_017591491.1XP_017446980.1  CD44 antigen isoform X5

  6. XM_017591492.1XP_017446981.1  CD44 antigen isoform X6

    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  7. XM_008762058.2XP_008760280.1  CD44 antigen isoform X7

    Related
    ENSRNOP00000008760.6, ENSRNOT00000008760.7
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...
  8. XM_006234631.3XP_006234693.1  CD44 antigen isoform X8

    See identical proteins and their annotated locations for XP_006234693.1

    UniProtKB/Swiss-Prot
    P26051
    UniProtKB/TrEMBL
    O70509
    Related
    ENSRNOP00000009073.6, ENSRNOT00000009073.7
    Conserved Domains (1) summary
    cd03516
    Location:29172
    Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    88236830..88324125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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