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top1 DNA topoisomerase I [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2540032, updated on 4-Dec-2018

Summary

Gene symbol
top1
Gene description
DNA topoisomerase I
Primary source
PomBase:SPBC1703.14c
Locus tag
SPBC1703.14c
Gene type
protein coding
RNA name
DNA topoisomerase I
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces

Genomic context

See top1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
3
Sequence:
Chromosome: II; NC_003423.3 (2941734..2944593, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene putative inorganic phosphate transporter Neighboring gene vacuolar sorting protein Vps33 Neighboring gene miscRNA Neighboring gene NAD-dependent epimerase/dehydratase family protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the top1 gene: The top1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA topoisomerase type I activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin assembly or disassembly ISO
Inferred from Sequence Orthology
more info
 
chromatin organization IGI
Inferred from Genetic Interaction
more info
PubMed 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin NAS
Non-traceable Author Statement
more info
 
nucleolus HDA PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase I
NP_596209.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    2941734..2944593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022128.2NP_596209.1  DNA topoisomerase I [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596209.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P07799
    Conserved Domains (4) summary
    smart00435
    Location:339787
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:412608
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:193408
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:745812
    Topo_C_assoc; C-terminal topoisomerase domain
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