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tts1 tetra-spanning protein 1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539923, updated on 15-Apr-2026
Official Symbol
tts1
Official Full Name
tetra-spanning protein 1
Primary source
PomBase:SPBC1539.04
Locus tag
SPOM_SPBC1539.04
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See tts1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (4368342..4369816)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene argininosuccinate lyase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COG complex subunit Cog3 Neighboring gene acyl-coenzyme A binding protein

Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Tts1, the fission yeast homologue of the TMEM33 family, functions in NE remodeling during mitosis. Zhang D, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103238, Free PMC Article
  2. The cortical ER network limits the permissive zone for actomyosin ring assembly. Zhang D, et al. Curr Biol, 2010 Jun 8. PMID 20434336
  3. Characterization of cwl1+, a gene from Schizosaccharomyces pombe whose overexpression causes cell lysis. Godoy C, et al. Yeast, 1996 Aug. PMID 8873452
  4. Plasma membrane tethering of the cortical ER necessitates its finely reticulated architecture. Zhang D, et al. Curr Biol, 2012 Nov 6. PMID 23041194
  5. The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast. Zou CX, et al. PLoS Biol, 2023 Nov. PMID 37939137, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in addition to maintaining the cortical endoplasmic reticulum network, Tts1 also plays a role in nuclear envelope remodeling during mitosis
    Title: Tts1, the fission yeast homologue of the TMEM33 family, functions in NE remodeling during mitosis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables membrane bending activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle pole body insertion into the nuclear envelope IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic spindle pole body localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus HDA PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum EXP
Inferred from Experiment
more info
 PubMed 
is_active_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tetra-spanning protein 1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    4368342..4369816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023838.3 → NP_596818.1  tetra-spanning protein 1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_596818.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Y7Z5
    Conserved Domains (1) summary
    pfam03661
    Location:23 → 256
    UPF0121; uncharacterized protein family (UPF0121)
Nucleotide Protein
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