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Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25399, updated on 12-Jan-2022

Summary

Official Symbol
Cacna2d1provided by RGD
Official Full Name
calcium voltage-gated channel auxiliary subunit alpha2delta 1provided by RGD
Primary source
RGD:2247
See related
Ensembl:ENSRNOG00000033531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CCHLA2; Cacna2; DHSCCA
Summary
Enables voltage-gated calcium channel activity. Involved in calcium ion transport and regulation of ion transmembrane transport. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is anchored component of postsynaptic membrane and anchored component of presynaptic active zone membrane. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Nov 2021]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Muscle (RPKM 1317.2), Brain (RPKM 301.1) and 4 other tissues See more
Orthologs
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Genomic context

See Cacna2d1 in Genome Data Viewer
Location:
4q12
Exon count:
39
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (18950611..19374969, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (15706974..16130848, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2-like Neighboring gene uncharacterized LOC103692033 Neighboring gene hepatocyte growth factor Neighboring gene hypothetical LOC100360215 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle cell action potential involved in contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle cell action potential involved in contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane depolarization during bundle of His cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane depolarization during bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane repolarization during action potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of L-type voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in anchored component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in anchored component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-1
Names
Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type)
calcium channel, voltage-dependent, alpha2/delta subunit 1
voltage-gated calcium channel subunit alpha-2/delta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110847.1NP_001104317.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001104317.1

    Status: PROVISIONAL

    Source sequence(s)
    AF400662
    UniProtKB/TrEMBL
    Q8VHS9
    Conserved Domains (5) summary
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446530
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    pfam08473
    Location:538622
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:537804
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  2. NM_001110848.1NP_001104318.1  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001104318.1

    Status: PROVISIONAL

    Source sequence(s)
    AF486276
    UniProtKB/TrEMBL
    Q8CFG7
    Related
    ENSRNOP00000044940.5, ENSRNOT00000042914.5
    Conserved Domains (5) summary
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446531
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    pfam08473
    Location:543627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:623809
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
  3. NM_012919.3NP_037051.2  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_037051.2

    Status: PROVISIONAL

    Source sequence(s)
    AF286488
    UniProtKB/TrEMBL
    Q9ERS3
    Conserved Domains (5) summary
    cd01463
    Location:239417
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:446531
    Cache_1; Cache domain
    pfam08399
    Location:104223
    VWA_N; VWA N-terminal
    pfam08473
    Location:543627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl21471
    Location:636816
    RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    18950611..19374969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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