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dsk1 SR protein-specific kinase Dsk1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539847, updated on 9-Mar-2023

Summary

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Gene symbol
dsk1
Gene description
SR protein-specific kinase Dsk1
Locus tag
SPBC530.14c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See dsk1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_003423.3 (824805..827995, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene miscRNA Neighboring gene palmitoyl protein thioesterase-dolichol pyrophosphate phosphatase fusion 1 Neighboring gene Lsk1-associated cyclin Neighboring gene putative spermidine family transporter Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene putative spermidine family transporter Neighboring gene miscRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1 Kinase. Wu M, et al. J Proteome Res, 2020 Apr 3. PMID 32062975
  2. LAMMER kinase Kic1 is involved in pre-mRNA processing. Tang Z, et al. Exp Cell Res, 2011 Oct 1. PMID 21745468
  3. The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation. Tang Z, et al. Exp Cell Res, 2003 Feb 1. PMID 12565823
  4. Identification and characterization of a novel gene, hos3+, the function of which is necessary for growth under high osmotic stress in fission yeast. Aoyama K, et al. Biosci Biotechnol Biochem, 2000 May. PMID 10879493
  5. Fission yeast mitotic regulator Dsk1 is an SR protein-specific kinase. Tang Z, et al. J Biol Chem, 1998 Mar 6. PMID 9488736

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the SR protein kinase Dsk1 is required for efficient splicing of introns with suboptimal splice sites.
    Title: SR protein kinases promote splicing of nonconsensus introns.
  2. Dsk1 is mainly localized in the nucleus during G(2) phase and at mitosis. It oscillates in a cell cycle-dependent manner.
    Title: Interacting factors and cellular localization of SR protein-specific kinase Dsk1.
  3. Data show that Srp1p and Srp2p are the in vivo substrates of Dsk1p in Schizosaccharomyces pombe
    Title: Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SR protein-specific kinase Dsk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    824805..827995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001021234.2 → NP_595327.1  SR protein-specific kinase Dsk1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_595327.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59749, P36616
    Conserved Domains (2) summary
    smart00220
    Location:81 → 516
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14136
    Location:69 → 516
    STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
Nucleotide Protein
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Gene LinkOut

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Research Materials