U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCTD13 potassium channel tetramerization domain containing 13 [ Homo sapiens (human) ]

Gene ID: 253980, updated on 11-Jun-2025
Official Symbol
KCTD13provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 13provided by HGNC
Primary source
HGNC:HGNC:22234
See related
Ensembl:ENSG00000174943 MIM:608947; AllianceGenome:HGNC:22234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1
Summary
Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See KCTD13 in Genome Data Viewer
Location:
16p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29906339..29926226, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30188975..30208863, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29917660..29937547, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29874668-29875205 Neighboring gene CDIP transferase opposite strand, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:29889007-29889508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:29889509-29890008 Neighboring gene seizure related 6 homolog like 2 Neighboring gene Sharpr-MPRA regulatory region 6067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29912830-29913534 Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7344 Neighboring gene KCTD13 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7345 Neighboring gene transmembrane protein 219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7346 Neighboring gene uncharacterized LOC124903762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:29985672-29986443 Neighboring gene TAO kinase 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that KCTD13 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with KCTD13 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Names
BTB/POZ domain-containing protein KCTD13
CTD-2574D22.4
TNFAIP1-like protein
polymerase delta-interacting protein 1
potassium channel tetramerisation domain containing 13

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410898.1NP_001397827.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120114, KF459558
    Consensus CDS
    CCDS92133.1
    UniProtKB/TrEMBL
    A0A3B3IS45
    Related
    ENSP00000497126.1, ENST00000567795.3
  2. NM_178863.5NP_849194.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 1

    See identical proteins and their annotated locations for NP_849194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AF289573, BC036228, BI553707
    Consensus CDS
    CCDS10661.1
    UniProtKB/Swiss-Prot
    A8K0R5, Q8WZ19, Q96P93, Q96SA1
    Related
    ENSP00000455785.1, ENST00000568000.6
    Conserved Domains (1) summary
    cd18400
    Location:40142
    BTB_POZ_KCTD13_BACURD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13)

RNA

  1. NR_110933.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF289573, AK097407, BC036228, BI553707
    Related
    ENST00000566842.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    29906339..29926226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545783.4XP_011544085.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X1

    Conserved Domains (2) summary
    smart00225
    Location:42137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:43133
    BTB; BTB/POZ domain

RNA

  1. XR_007064863.1 RNA Sequence

  2. XR_950767.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30188975..30208863 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379993.1XP_054235968.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X1

  2. XM_054379994.1XP_054235969.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X2

RNA

  1. XR_008489071.1 RNA Sequence

  2. XR_008489070.1 RNA Sequence