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KCTD13 potassium channel tetramerization domain containing 13 [ Homo sapiens (human) ]

Gene ID: 253980, updated on 25-Jan-2022

Summary

Official Symbol
KCTD13provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 13provided by HGNC
Primary source
HGNC:HGNC:22234
See related
Ensembl:ENSG00000174943 MIM:608947; AllianceGenome:HGNC:22234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1
Summary
Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of Rho protein signal transduction; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues See more
Orthologs
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Genomic context

See KCTD13 in Genome Data Viewer
Location:
16p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29906335..29926226, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29917660..29937547, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CDIP transferase opposite strand, pseudogene Neighboring gene seizure related 6 homolog like 2 Neighboring gene Sharpr-MPRA regulatory region 6067 Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene KCTD13 divergent transcript Neighboring gene transmembrane protein 219

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that KCTD13 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with KCTD13 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
Names
BTB/POZ domain-containing protein KCTD13
CTD-2574D22.4
TNFAIP1-like protein
polymerase delta-interacting protein 1
potassium channel tetramerisation domain containing 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178863.5NP_849194.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

    See identical proteins and their annotated locations for NP_849194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AF289573, BC036228, BI553707
    Consensus CDS
    CCDS10661.1
    UniProtKB/Swiss-Prot
    Q8WZ19
    Related
    ENSP00000455785.1, ENST00000568000.6
    Conserved Domains (1) summary
    cd18400
    Location:40142
    BTB_POZ_KCTD13_BACURD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 13 (KCTD13)

RNA

  1. NR_110933.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF289573, AK097407, BC036228, BI553707
    Related
    ENST00000566842.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29906335..29926226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545783.3XP_011544085.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X1

    Conserved Domains (2) summary
    smart00225
    Location:42137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:43133
    BTB; BTB/POZ domain
  2. XM_017023104.2XP_016878593.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X3

  3. XM_011545784.3XP_011544086.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X2

  4. XM_017023105.2XP_016878594.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X4

  5. XM_017023106.2XP_016878595.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform X5

    Related
    ENSP00000497126.1, ENST00000567795.3

RNA

  1. XR_001751887.2 RNA Sequence

  2. XR_001751888.2 RNA Sequence

  3. XR_950767.3 RNA Sequence

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