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tpx1 thioredoxin peroxidase Tpx1 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539572, updated on 9-Sep-2018

Summary

Gene symbol
tpx1
Gene description
thioredoxin peroxidase Tpx1
Locus tag
SPCC576.03c
Gene type
protein coding
RNA name
thioredoxin peroxidase Tpx1
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces

Genomic context

See tpx1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
1
Sequence:
Chromosome: III; NC_003421.2 (2084942..2085706, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene putative sulfonate dioxygenase Neighboring gene hypothetical protein Neighboring gene putative hydantoin racemase family protein Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene BAX inhibitor family protein Bxi1 Neighboring gene nuclear export factor sac3

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular detoxification of hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
thioredoxin peroxidase Tpx1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    2084942..2085706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023421.2NP_588430.1  thioredoxin peroxidase Tpx1 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588430.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74887
    Conserved Domains (2) summary
    COG0450
    Location:1192
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:5176
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
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