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qns1 glutamine-dependent NAD(+) synthetase [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539475, updated on 6-Jul-2026
Official Symbol
qns1
Official Full Name
glutamine-dependent NAD(+) synthetase
Primary source
PomBase:SPCC553.02
Locus tag
SPOM_SPCC553.02
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See qns1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003421.2 (305618..308619, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp9 Neighboring gene AAA family ATPase Pex1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA recombination protein Dbl2

Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Arrayed CRISPRi library to suppress genes required for Schizosaccharomyces pombe viability. Ishikawa K, et al. J Cell Biol, 2025 Jan 6. PMID 39378339, Free PMC Article
  2. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
  3. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
  4. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
  5. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD+ biosynthetic process from L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD+ biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD+ biosynthetic process via the salvage pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol HDA PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
glutamine-dependent NAD(+) synthetase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    305618..308619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022764.3 → NP_587771.1  glutamine-dependent NAD(+) synthetase [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587771.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O74940
    Conserved Domains (3) summary
    cd07570
    Location:6 → 286
    GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
    PLN02339
    Location:3 → 695
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
    cd00553
    Location:330 → 651
    NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...
Nucleotide Protein
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