U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp1b3 ATPase Na+/K+ transporting subunit beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25390, updated on 24-Apr-2022

Summary

Official Symbol
Atp1b3provided by RGD
Official Full Name
ATPase Na+/K+ transporting subunit beta 3provided by RGD
Primary source
RGD:2172
See related
Ensembl:ENSRNOG00000011501 AllianceGenome:RGD:2172
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NKAB3S
Summary
Enables P-type sodium:potassium-exchanging transporter activity. Involved in potassium ion transport and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 800.9), Thymus (RPKM 684.8) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp1b3 in Genome Data Viewer
Location:
8q31
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96910265..96941592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104190032..104221342, complement)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene transcription factor Dp-2 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 1 Neighboring gene 60S ribosomal protein L31-like Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 21 Neighboring gene ring finger protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of transmembrane electrochemical gradient IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-3
Names
ATPB-3
ATPase, Na+/K+ transporting, beta 3 polypeptide
ATPase, Na+K+ transporting, beta polypeptide 3
Na+/K+ -ATPase beta 3 subunit
sodium/potassium-dependent ATPase subunit beta-3
NP_037045.1
XP_038936805.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012913.1NP_037045.1  sodium/potassium-transporting ATPase subunit beta-3

    See identical proteins and their annotated locations for NP_037045.1

    Status: PROVISIONAL

    Source sequence(s)
    D84450
    UniProtKB/Swiss-Prot
    Q63377
    Related
    ENSRNOP00000015475.5, ENSRNOT00000015476.6
    Conserved Domains (1) summary
    TIGR01107
    Location:1279
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    96910265..96941592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080877.1XP_038936805.1  sodium/potassium-transporting ATPase subunit beta-3 isoform X1

    Conserved Domains (1) summary
    cl08255
    Location:1222
    Na_K-ATPase; Sodium / potassium ATPase beta chain