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Arrb2 arrestin, beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25388, updated on 5-Jan-2022

Summary

Official Symbol
Arrb2provided by RGD
Official Full Name
arrestin, beta 2provided by RGD
Primary source
RGD:2157
See related
Ensembl:ENSRNOG00000019308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BARRES
Summary
Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of apoptotic process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Biomarker of hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Thymus (RPKM 253.6), Spleen (RPKM 193.9) and 9 other tissues See more
Orthologs
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Genomic context

See Arrb2 in Genome Data Viewer
Location:
10q24
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55146887..55154854)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57040252..57048045)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene mediator complex subunit 11 Neighboring gene C-X-C motif chemokine ligand 16 Neighboring gene zinc finger, MYND-type containing 15

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC105502

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables alpha-1A adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-1B adrenergic receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables angiotensin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables arrestin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables follicle-stimulating hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables platelet activating factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type 1 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables type 2A serotonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 2A serotonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in follicle-stimulating hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012911.2NP_037043.1  beta-arrestin-2

    See identical proteins and their annotated locations for NP_037043.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000220
    UniProtKB/Swiss-Prot
    P29067
    Related
    ENSRNOP00000026207.7, ENSRNOT00000026207.8
    Conserved Domains (2) summary
    smart01017
    Location:199350
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    55146887..55154854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085270.1XP_038941198.1  beta-arrestin-2 isoform X3

    Conserved Domains (2) summary
    smart01017
    Location:199236
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:19175
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. XM_039085269.1XP_038941197.1  beta-arrestin-2 isoform X2

    Conserved Domains (2) summary
    smart01017
    Location:109260
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:685
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  3. XM_039085267.1XP_038941195.1  beta-arrestin-2 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:198349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  4. XM_039085268.1XP_038941196.1  beta-arrestin-2 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:198349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  5. XM_039085266.1XP_038941194.1  beta-arrestin-2 isoform X1

    Related
    ENSRNOP00000095625.1, ENSRNOT00000108666.1
    Conserved Domains (2) summary
    smart01017
    Location:198349
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:18174
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. XR_005489692.1 RNA Sequence

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