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mis18 kinetochore protein Mis18 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538763, updated on 4-Feb-2026
Official Symbol
mis18
Official Full Name
kinetochore protein Mis18
Primary source
PomBase:SPCC970.12
Locus tag
SPOM_SPCC970.12
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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See mis18 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003421.2 (513931..514807, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome b5 reductase Neighboring gene mannan endo-1,6-alpha-mannosidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA repair endonuclease XPF Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast. Zhang M, et al. Cell Mol Life Sci, 2021 Jan. PMID 32318758, Free PMC Article
  2. Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation. Suma M, et al. G3 (Bethesda), 2018 Jul 31. PMID 29925533, Free PMC Article
  3. Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly. London N, et al. Curr Biol, 2023 Oct 9. PMID 37714149, Free PMC Article
  4. Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. Subramanian L, et al. EMBO Rep, 2016 Apr. PMID 26921242, Free PMC Article
  5. Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Pidoux AL, et al. Mol Cell, 2009 Feb 13. PMID 19217404, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
    Title: Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly.
  2. Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast.
    Title: Centromere targeting of Mis18 requires the interaction with DNA and H2A-H2B in fission yeast.
  3. Results confirm that the binding of Mis19 to Mis18 requires the N terminus of Mis19 and two Mis18 C-terminus.
    Title: Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.
  4. findings show that the oligomerization of S. pombe Mis18, mediated via its conserved N-terminal Yippee-like domain, is crucial for its centromere localization and function
    Title: Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.
  5. Mis16-Mis18-Mis19-Mis20 CENP-A-recruiting complex, which is functional in the G1-S phase, may be counteracted by the SWI/SNF chromatin-remodeling complex and non-sense-mediated mRNA decay, which may prevent CENP-A deposition at the centromere.
    Title: Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
  6. we report that the Mis16-Mis18 complex is required for centromere localization of Scm3(Sp)
    Title: Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
contributes_to chromatin-protein adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CENP-A containing chromatin assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in CENP-A containing chromatin assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in pericentric heterochromatin organization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of CENP-A recruiting complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
kinetochore protein Mis18

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    513931..514807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001022847.3 → NP_587854.2  kinetochore protein Mis18 [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_587854.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9P802
    Conserved Domains (1) summary
    pfam03226
    Location:21 → 115
    Yippee-Mis18; Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Nucleotide Protein
Heading Accession and Version

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