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ctp1 CtIP family endonuclease [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2538706, updated on 18-Sep-2024

Summary

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Official Symbol
ctp1
Official Full Name
CtIP family endonuclease
Primary source
PomBase:SPCC338.08
Locus tag
SPOM_SPCC338.08
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
mug38; nip1; slr9
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Genomic context

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Location:
chromosome: III
Exon count:
2
Sequence:
Chromosome: III; NC_003421.2 (1358737..1360232, complement)

Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene methyltransferase Rrg1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome c oxidase subunit V Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ctp1 protein-DNA filaments promote DNA bridging and DNA double-strand break repair. Andres SN, et al. J Biol Chem, 2019 Mar 1. PMID 30626735, Free PMC Article
  2. Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair. Ma L, et al. Nucleic Acids Res, 2015 Sep 3. PMID 26130711, Free PMC Article
  3. Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks. Dodson GE, et al. Cell Cycle, 2010 Apr 15. PMID 20421724, Free PMC Article
  4. CtIP/Ctp1/Sae2, molecular form fit for function. Andres SN, et al. DNA Repair (Amst), 2017 Aug. PMID 28623092, Free PMC Article
  5. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair. Andres SN, et al. Nat Struct Mol Biol, 2015 Feb. PMID 25580577, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
    Title: A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
  2. an important role for Ctp1-regulated DNA strand coordination required for DNA DSB repair in S. pombe
    Title: Ctp1 protein-DNA filaments promote DNA bridging and DNA double-strand break repair.
  3. CtIP/Ctp1/Sae2/Com1 role in removal of DNA double strand breaks through DSB repair by homologous recombination is reviewed.
    Title: CtIP/Ctp1/Sae2, molecular form fit for function.
  4. a mre11 mutant defective in endonucleolytic activity, the same mutant lacking Ctp1, or the triple mutant also lacking the putative hairpin nuclease Pso2 showed wild-type levels of repair. Thus, MRN (Mre11-Rad50-Nbs1)may act to recruit the hairpin opening activity that allows subsequent repair
    Title: Nonhomologous End-Joining with Minimal Sequence Loss Is Promoted by the Mre11-Rad50-Nbs1-Ctp1 Complex in Schizosaccharomyces pombe.
  5. The authors concludes that the intracellular Ctp1 C-terminal portion is essential for clipping, while the N-terminal portion is sufficient for DNA double-strand break end-resection.
    Title: Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.
  6. Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.
    Title: Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.
  7. these data propose that release of the MRN complex and Ku from DNA ends by Mre11 nuclease activity and Ctp1 is a critical step required to expose ssDNA for replication protein A localization and ensuing homologous recombination repair.
    Title: Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.
  8. In fission yeast, found only one class of oligonucleotides bound to Rec12 ranging in length from 17 to 27 nucleotides. Ctp1, Rad50, and the nuclease activity of Rad32, the fission yeast homolog of Mre11, are required for endonucleolytic Rec12 removal.
    Title: Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast.
  9. Rad32 nuclease has the catalytic site for Rec12-oligonucleotide generation and is activated by Ctp1, which plays an additional role in meiotic recombination.
    Title: Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
  10. Tethering of Ctp1 to a flexible Nbs1 arm suggests a mechanism for restricting DNA end processing and homologous recombination activities of Sae2/Ctp1/CtIP to the immediate vicinity of double-strand breaks.
    Title: Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables DNA end binding EXP
Inferred from Experiment
more info
 PubMed 
enables DNA-DNA tethering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Y-form DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables bubble DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-strand/single-strand DNA junction binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables double-stranded DNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endodeoxyribonuclease activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flap-structured DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene conversion at mating-type locus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic recombination-dependent replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stalled replication fork localization to nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CtIP family endonuclease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003421.2 Reference assembly

    Range
    1358737..1360232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001023148.4 → NP_588159.2  CtIP family endonuclease [Schizosaccharomyces pombe]

    See identical proteins and their annotated locations for NP_588159.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A9LJ21, O74986
    Conserved Domains (1) summary
    pfam08573
    Location:210 → 292
    SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
Nucleotide Protein
Heading Accession and Version

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