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ZDHHC20 zinc finger DHHC-type palmitoyltransferase 20 [ Homo sapiens (human) ]

Gene ID: 253832, updated on 22-Sep-2022

Summary

Official Symbol
ZDHHC20provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 20provided by HGNC
Primary source
HGNC:HGNC:20749
See related
Ensembl:ENSG00000180776 MIM:617972; AllianceGenome:HGNC:20749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC20; DHHC-20; 4933421L13Rik
Summary
Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in intracellular membrane-bounded organelle and plasma membrane. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach (RPKM 21.2), urinary bladder (RPKM 18.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZDHHC20 in Genome Data Viewer
Location:
13q12.11
Exon count:
20
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (21372571..21459303, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20566901..20653645, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21946710..22033442, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial intermediate peptidase pseudogene 3 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 52 Neighboring gene nitric oxide synthase-like Neighboring gene RNA, 5S ribosomal pseudogene 25 Neighboring gene uncharacterized LOC124903131 Neighboring gene H2B histone pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger, DHHC-type containing 20 (ZDHHC20) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25952, MGC126005

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation by host of viral process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC20
Names
DHHC domain-containing cysteine-rich protein 20
acyltransferase ZDHHC20
probable palmitoyltransferase ZDHHC20
zinc finger DHHC domain-containing protein 20
zinc finger DHHC-type containing 20
NP_001273567.1
NP_001316988.1
NP_694983.2
XP_006719859.1
XP_006719860.1
XP_011533332.1
XP_016876014.1
XP_047286198.1
XP_047286199.1
XP_047286200.1
XP_047286201.1
XP_047286202.1
XP_047286203.1
XP_047286204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286638.2NP_001273567.1  palmitoyltransferase ZDHHC20 isoform 2

    See identical proteins and their annotated locations for NP_001273567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK299354, AL136219, BU685378
    Consensus CDS
    CCDS73551.1
    UniProtKB/Swiss-Prot
    Q5W0Z9
    UniProtKB/TrEMBL
    B4DRN8
    Related
    ENSP00000443236.1, ENST00000542645.5
    Conserved Domains (1) summary
    cl19890
    Location:52238
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001330059.2NP_001316988.1  palmitoyltransferase ZDHHC20 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site, contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB040396, AL136219, BC067898, BU685378, CR737535, DR003340
    Consensus CDS
    CCDS81758.1
    UniProtKB/Swiss-Prot
    Q5W0Z9, Q6NVU8
    Related
    ENSP00000383433.3, ENST00000400590.8
    Conserved Domains (1) summary
    cl19890
    Location:16301
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_153251.4NP_694983.2  palmitoyltransferase ZDHHC20 isoform 1

    See identical proteins and their annotated locations for NP_694983.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL136219, BC050367, BG720734, BU685378
    Consensus CDS
    CCDS45017.1
    UniProtKB/Swiss-Prot
    Q5W0Z9
    Related
    ENSP00000371905.3, ENST00000382466.7
    Conserved Domains (1) summary
    cl19890
    Location:16301
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_104486.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL136219, BC067898, BU685378
  2. NR_104487.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL136219, BC034944, BC110517, BU685378

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    21372571..21459303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719796.2XP_006719859.1  palmitoyltransferase ZDHHC20 isoform X1

    See identical proteins and their annotated locations for XP_006719859.1

    Conserved Domains (1) summary
    cl19890
    Location:16301
    DHHC; DHHC palmitoyltransferase
  2. XM_006719797.2XP_006719860.1  palmitoyltransferase ZDHHC20 isoform X2

    See identical proteins and their annotated locations for XP_006719860.1

    Conserved Domains (1) summary
    cl19890
    Location:16301
    DHHC; DHHC palmitoyltransferase
  3. XM_047430246.1XP_047286202.1  palmitoyltransferase ZDHHC20 isoform X8

  4. XM_047430245.1XP_047286201.1  palmitoyltransferase ZDHHC20 isoform X7

  5. XM_047430244.1XP_047286200.1  palmitoyltransferase ZDHHC20 isoform X6

    UniProtKB/TrEMBL
    B4DRN8
  6. XM_047430243.1XP_047286199.1  palmitoyltransferase ZDHHC20 isoform X4

  7. XM_017020525.2XP_016876014.1  palmitoyltransferase ZDHHC20 isoform X5

    Conserved Domains (1) summary
    cl19890
    Location:44230
    DHHC; DHHC palmitoyltransferase
  8. XM_047430247.1XP_047286203.1  palmitoyltransferase ZDHHC20 isoform X10

  9. XM_047430248.1XP_047286204.1  palmitoyltransferase ZDHHC20 isoform X10

  10. XM_011535030.4XP_011533332.1  palmitoyltransferase ZDHHC20 isoform X9

    Conserved Domains (1) summary
    cl19890
    Location:58153
    DHHC; DHHC palmitoyltransferase
  11. XM_047430242.1XP_047286198.1  palmitoyltransferase ZDHHC20 isoform X3

    Related
    ENSP00000313583.9, ENST00000320220.13

RNA

  1. XR_007063672.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    20566901..20653645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)