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Amh anti-Mullerian hormone [ Rattus norvegicus (Norway rat) ]

Gene ID: 25378, updated on 6-Jul-2026
Official Symbol
Amhprovided by RGD
Official Full Name
anti-Mullerian hormoneprovided by RGD
Primary source
RGD:2108
See related
Ensembl:ENSRNOG00000019377 AllianceGenome:RGD:2108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MIS
Summary
Enables transforming growth factor beta receptor binding activity. Involved in several processes, including negative regulation of ovarian follicle development; positive regulation of NF-kappaB transcription factor activity; and preantral ovarian follicle growth. Acts upstream of or within urogenital system development. Located in extracellular space. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 20.2), Muscle (RPKM 8.9) and 8 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Amh in Genome Data Viewer
Location:
7q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9557451..9559867, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8906776..8909192, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene splicing factor 3A subunit 2 Neighboring gene pleckstrin homology domain containing J1 Neighboring gene DOT1 like histone lysine methyltransferase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruption†. Sominsky L, et al. Biol Reprod, 2021 Jul 2. PMID 33709094
  2. Isolation of the rat gene for Mullerian inhibiting substance. Haqq C, et al. Genomics, 1992 Apr. PMID 1572639
  3. Müllerian inhibitory substance induces growth of rat preantral ovarian follicles. McGee EA, et al. Biol Reprod, 2001 Jan. PMID 11133686
  4. Extracellular domain of YWK-II, a human sperm transmembrane protein, interacts with rat Müllerian-inhibiting substance. Tian XY, et al. Reproduction, 2001 Jun. PMID 11373173
  5. Increased expression of Müllerian-inhibiting substance correlates with inhibition of follicular growth in the developing ovary of rats treated with E2 benzoate. Ikeda Y, et al. Endocrinology, 2002 Jan. PMID 11751622

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat.
    Title: Mechanisms of DHEA-induced AMH increase in the ovarian tissues of PCOS rat.
  2. Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruptiondagger.
    Title: Ovarian follicles are resistant to monocyte perturbations-implications for ovarian health with immune disruption†.
  3. Effects of Ovarian Transplant on Anti-Mullerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
    Title: Effects of Ovarian Transplant on Anti-Müllerian Hormone, Kisspeptin-1, and Kisspeptin-1 Receptor Levels in Rats.
  4. Role of non-classical effects of testosterone and epitestosterone on AMH balance and testicular development parameters.
    Title: Role of non-classical effects of testosterone and epitestosterone on AMH balance and testicular development parameters.
  5. The study uncovers a new role for AMH in regulating gonadotrope function and suggests that AMH participates in the postnatal elevation of FSH secretion in females.
    Title: Anti-Müllerian hormone: a new actor of sexual dimorphism in pituitary gonadotrope activity before puberty.
  6. AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons.
    Title: Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.
  7. Resveratrol reduced antimullerian hormone levels in rat model of polycystic ovary syndrome.
    Title: Effects of Resveratrol on Ovarian Morphology, Plasma Anti-Mullerian Hormone, IGF-1 Levels, and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome.
  8. AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly.
    Title: Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly.
  9. In ovaries from adult cycling rats AMH protein is localized in large primary and secondary follicles and not in primordial or small primary follicles, with its highest expression in the largest preantral follicles.
    Title: Distribution and responsiveness of rat anti-Müllerian hormone during ovarian development and VCD-induced ovotoxicity.
  10. Mullerian inhibiting substance regulates gonadotropin gene expression
    Title: Regulation of gonadotropin gene expression by Mullerian inhibiting substance.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables type II transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables type II transforming growth factor beta receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Leydig cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in Leydig cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Mullerian duct regression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mullerian duct regression IEA
Inferred from Electronic Annotation
more info
  
involved_in Mullerian duct regression ISO
Inferred from Sequence Orthology
more info
  
involved_in Mullerian duct regression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in Mullerian duct regression TAS
Traceable Author Statement
more info
 PubMed 
involved_in anti-Mullerian hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anti-Mullerian hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in anti-Mullerian hormone receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in development of primary male sexual characteristics IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gonad development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ovarian follicle development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ovarian follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in preantral ovarian follicle growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sex determination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within urogenital system development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of serine/threonine protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of serine/threonine protein kinase complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
anti-Muellerian hormone
Names
Anti - Mullerian hormone (Mulerian inhibiting substance)
muellerian-inhibiting factor
muellerian-inhibiting substance

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012902.2 → NP_037034.1  anti-Muellerian hormone precursor

    See identical proteins and their annotated locations for NP_037034.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    P49000
    Related
    ENSRNOP00000026220.1, ENSRNOT00000026220.4
    Conserved Domains (2) summary
    smart00204
    Location:455 → 553
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam04709
    Location:74 → 417
    AMH_N; Anti-Mullerian hormone, N terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9557451..9559867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49000.1 GenPept UniProtKB/Swiss-Prot:P49000

Gene LinkOut

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