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WDR27 WD repeat domain 27 [ Homo sapiens (human) ]

Gene ID: 253769, updated on 25-Jan-2022

Summary

Official Symbol
WDR27provided by HGNC
Official Full Name
WD repeat domain 27provided by HGNC
Primary source
HGNC:HGNC:21248
See related
Ensembl:ENSG00000184465 AllianceGenome:HGNC:21248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

See WDR27 in Genome Data Viewer
Location:
6q27
Exon count:
44
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (169426420..169702063, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (169857307..170102125, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378148 Neighboring gene long intergenic non-protein coding RNA 2519 Neighboring gene chromosome 6 open reading frame 120 Neighboring gene PHD finger protein 10 Neighboring gene dynein light chain Tctex-type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
EBI GWAS Catalog
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC43690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
WD repeat-containing protein 27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046155.1 RefSeqGene

    Range
    5035..249852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1071

mRNA and Protein(s)

  1. NM_001202550.2NP_001189479.1  WD repeat-containing protein 27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons that result in the loss of an in-frame segment in the 5' coding region, and lacks another alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL513547, AW194823, BC131633, DB292377
    Consensus CDS
    CCDS56459.1
    UniProtKB/Swiss-Prot
    A2RRH5
    Related
    ENSP00000397869.1, ENST00000423258.5
    Conserved Domains (3) summary
    COG2319
    Location:454727
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:419456
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:418727
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001350623.2NP_001337552.1  WD repeat-containing protein 27 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031315, AL135910, AL513547
    Conserved Domains (2) summary
    sd00039
    Location:355392
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:354663
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001350624.2NP_001337553.1  WD repeat-containing protein 27 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform 4.
    Source sequence(s)
    AL513547
    Related
    ENSP00000497692.1, ENST00000647873.1
    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:39204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001350625.2NP_001337554.1  WD repeat-containing protein 27 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AL513547
    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:39204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_182552.5NP_872358.4  WD repeat-containing protein 27 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031315, AL513547, BC040606, DB292377
    Consensus CDS
    CCDS47520.2
    UniProtKB/Swiss-Prot
    A2RRH5
    Related
    ENSP00000416289.1, ENST00000448612.6
    Conserved Domains (4) summary
    COG2319
    Location:544865
    WD40; WD40 repeat [General function prediction only]
    pfam13900
    Location:847881
    GVQW; Putative domain of unknown function
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_146875.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031315, AL135910, AL513547
    Related
    ENST00000648472.1
  2. NR_146876.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL513547
    Related
    ENST00000649303.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    169426420..169702063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535688.3XP_011533990.1  WD repeat-containing protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011533990.1

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545853
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011535689.3XP_011533991.1  WD repeat-containing protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011533991.1

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545853
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011535687.3XP_011533989.1  WD repeat-containing protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011533989.1

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545853
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017010673.2XP_016866162.1  WD repeat-containing protein 27 isoform X18

  5. XM_017010671.2XP_016866160.1  WD repeat-containing protein 27 isoform X16

    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_017010670.2XP_016866159.1  WD repeat-containing protein 27 isoform X16

    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_011535694.3XP_011533996.1  WD repeat-containing protein 27 isoform X13

    Conserved Domains (3) summary
    COG2319
    Location:544690
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_017010660.2XP_016866149.1  WD repeat-containing protein 27 isoform X5

    Conserved Domains (3) summary
    COG2319
    Location:581854
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545854
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_017010659.2XP_016866148.1  WD repeat-containing protein 27 isoform X3

  10. XM_011535691.3XP_011533993.1  WD repeat-containing protein 27 isoform X8

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_017010669.2XP_016866158.1  WD repeat-containing protein 27 isoform X15

    Conserved Domains (2) summary
    sd00039
    Location:355392
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:354663
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_017010662.2XP_016866151.1  WD repeat-containing protein 27 isoform X8

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_011535692.3XP_011533994.1  WD repeat-containing protein 27 isoform X9

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. XM_011535685.3XP_011533987.1  WD repeat-containing protein 27 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  15. XM_011535682.3XP_011533984.1  WD repeat-containing protein 27 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:544885
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  16. XM_017010658.2XP_016866147.1  WD repeat-containing protein 27 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:544885
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  17. XM_011535684.3XP_011533986.1  WD repeat-containing protein 27 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  18. XM_011535690.3XP_011533992.1  WD repeat-containing protein 27 isoform X7

    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  19. XM_017010667.2XP_016866156.1  WD repeat-containing protein 27 isoform X12

  20. XM_017010666.2XP_016866155.1  WD repeat-containing protein 27 isoform X11

  21. XM_017010665.2XP_016866154.1  WD repeat-containing protein 27 isoform X11

  22. XM_017010663.2XP_016866152.1  WD repeat-containing protein 27 isoform X11

  23. XM_017010664.2XP_016866153.1  WD repeat-containing protein 27 isoform X11

  24. XM_011535693.3XP_011533995.1  WD repeat-containing protein 27 isoform X10

    Conserved Domains (3) summary
    COG2319
    Location:544750
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  25. XM_017010668.2XP_016866157.1  WD repeat-containing protein 27 isoform X14

  26. XM_017010672.2XP_016866161.1  WD repeat-containing protein 27 isoform X17

  27. XM_011535697.3XP_011533999.1  WD repeat-containing protein 27 isoform X20

    Conserved Domains (3) summary
    COG2319
    Location:15356
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  28. XM_011535696.3XP_011533998.1  WD repeat-containing protein 27 isoform X19

    Conserved Domains (3) summary
    COG2319
    Location:15356
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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