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Vcam1 vascular cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25361, updated on 5-Apr-2021

Summary

Symbol
Vcam1provided by RGD
Full Name
vascular cell adhesion molecule 1provided by RGD
Primary source
RGD:3952
See related
Ensembl:ENSRNOG00000014333
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
VCAM1B
Summary
binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 1735.8), Thymus (RPKM 230.5) and 4 other tissues See more
Orthologs
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Genomic context

See Vcam1 in Genome Data Viewer
Location:
2q41
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204038120..204057852, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219071193..219090931, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L13 Neighboring gene ribosomal protein S27a, pseudogene 24 Neighboring gene uncharacterized LOC120100924 Neighboring gene G-protein coupled receptor 88

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC108734

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
amine metabolic process ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
cardiac neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion in response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
chorio-allantoic fusion ISO
Inferred from Sequence Orthology
more info
 
chronic inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic placenta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
membrane to membrane docking ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex ISO
Inferred from Sequence Orthology
more info
 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
filopodium ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus ISO
Inferred from Sequence Orthology
more info
 
podosome ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular cell adhesion protein 1
Names
V-CAM 1
VCAM-1
vascular cell adhesion protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012889.2NP_037021.1  vascular cell adhesion protein 1 precursor

    See identical proteins and their annotated locations for NP_037021.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000078
    UniProtKB/Swiss-Prot
    P29534
    Related
    ENSRNOP00000019377.3, ENSRNOT00000019377.5
    Conserved Domains (6) summary
    cd07689
    Location:404502
    Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00408
    Location:238298
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:321400
    IG_like; Immunoglobulin like
    pfam13895
    Location:514596
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:604672
    Ig_3; Immunoglobulin domain
    cl11960
    Location:3298
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    204038120..204057852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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