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CADM2 cell adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 253559, updated on 23-Nov-2021

Summary

Official Symbol
CADM2provided by HGNC
Official Full Name
cell adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:29849
See related
Ensembl:ENSG00000175161 MIM:609938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2
Summary
This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Expression
Biased expression in brain (RPKM 29.4), fat (RPKM 2.4) and 1 other tissue See more
Orthologs
NEW
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Genomic context

See CADM2 in Genome Data Viewer
Location:
3p12.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (84958989..86074429)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (85008140..86123579)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377193 Neighboring gene long intergenic non-protein coding RNA 2025 Neighboring gene small nucleolar RNA, H/ACA box 95 Neighboring gene microRNA 5688 Neighboring gene CADM2 antisense RNA 2 Neighboring gene THAP domain containing 12 pseudogene 2 Neighboring gene uncharacterized LOC102723364 Neighboring gene RNA, U6 small nuclear 1129, pseudogene Neighboring gene RN7SK pseudogene 284

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
GeneReviews: Not available
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104534, MGC138341, MGC138343

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell adhesion molecule 2
Names
immunoglobulin superfamily member 4D
nectin-like 3
nectin-like protein 3
synaptic cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167674.2NP_001161146.1  cell adhesion molecule 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001161146.1

    Status: REVIEWED

    Source sequence(s)
    AC107024, BC105999, BC112138
    Consensus CDS
    CCDS54614.1
    UniProtKB/Swiss-Prot
    Q8N3J6
    Related
    ENSP00000384575.2, ENST00000407528.6
    Conserved Domains (5) summary
    smart00294
    Location:388406
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:240303
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:242251
    Ig; Ig strand B [structural motif]
    cd05884
    Location:120223
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:26121
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
  2. NM_001167675.2NP_001161147.1  cell adhesion molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161147.1

    Status: REVIEWED

    Source sequence(s)
    AC107024, BC105999
    Consensus CDS
    CCDS54613.1
    UniProtKB/Swiss-Prot
    Q8N3J6
    UniProtKB/TrEMBL
    G3XHN4
    Related
    ENSP00000373200.3, ENST00000383699.8
    Conserved Domains (5) summary
    smart00294
    Location:357375
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:249312
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:251260
    Ig; Ig strand B [structural motif]
    cd05884
    Location:129232
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:35130
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
  3. NM_001256502.2NP_001243431.1  cell adhesion molecule 2 isoform 4

    See identical proteins and their annotated locations for NP_001243431.1

    Status: REVIEWED

    Source sequence(s)
    AC018361, AC107024, AC117452, AC119726
    UniProtKB/Swiss-Prot
    Q8N3J6
    Conserved Domains (4) summary
    smart00294
    Location:280298
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:33115
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:132195
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:131205
    IG_like; Immunoglobulin like
  4. NM_001256503.2NP_001243432.1  cell adhesion molecule 2 isoform 4

    See identical proteins and their annotated locations for NP_001243432.1

    Status: REVIEWED

    Source sequence(s)
    AC018361, AC107024, AC117452, AC119726
    UniProtKB/Swiss-Prot
    Q8N3J6
    Conserved Domains (4) summary
    smart00294
    Location:280298
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:33115
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:132195
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:131205
    IG_like; Immunoglobulin like
  5. NM_001256504.2NP_001243433.1  cell adhesion molecule 2 isoform 5

    See identical proteins and their annotated locations for NP_001243433.1

    Status: REVIEWED

    Source sequence(s)
    AC018361, AC107024, AC117452, AC119726, AC119729
    UniProtKB/Swiss-Prot
    Q8N3J6
    Conserved Domains (3) summary
    smart00294
    Location:240258
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:132195
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:33115
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  6. NM_001256505.2NP_001243434.1  cell adhesion molecule 2 isoform 5

    See identical proteins and their annotated locations for NP_001243434.1

    Status: REVIEWED

    Source sequence(s)
    AC018361, AC107024, AC117452, AC119726
    UniProtKB/Swiss-Prot
    Q8N3J6
    Conserved Domains (3) summary
    smart00294
    Location:240258
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:132195
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:33115
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  7. NM_001375960.1NP_001362889.1  cell adhesion molecule 2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729, AC132660
    Conserved Domains (5) summary
    smart00294
    Location:397415
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:249312
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:251260
    Ig; Ig strand B [structural motif]
    cd05884
    Location:129232
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:35130
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
  8. NM_001375961.1NP_001362890.1  cell adhesion molecule 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729, AC132660
    Conserved Domains (4) summary
    smart00294
    Location:341359
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:233296
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:134216
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:19113
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
  9. NM_001375964.1NP_001362893.1  cell adhesion molecule 2 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729, AC132660
    Conserved Domains (4) summary
    smart00294
    Location:311329
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:203266
    IGc2; Immunoglobulin C-2 Type
    cd07701
    Location:35129
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cl11960
    Location:129186
    Ig; Immunoglobulin domain
  10. NM_001375967.1NP_001362896.1  cell adhesion molecule 2 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729, AC132660
    Conserved Domains (4) summary
    smart00294
    Location:307325
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:199262
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:100182
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cl11960
    Location:2979
    Ig; Immunoglobulin domain
  11. NM_001375968.1NP_001362897.1  cell adhesion molecule 2 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729, AC132660
    Conserved Domains (3) summary
    smart00294
    Location:260278
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:152215
    IGc2; Immunoglobulin C-2 Type
    cl11960
    Location:66135
    Ig; Immunoglobulin domain
  12. NM_001381963.1NP_001368892.1  cell adhesion molecule 2 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC132660
    Conserved Domains (5) summary
    smart00294
    Location:348366
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:240303
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:242251
    Ig; Ig strand B [structural motif]
    cd05884
    Location:120223
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:26121
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
  13. NM_001381964.1NP_001368893.1  cell adhesion molecule 2 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC132660
    Conserved Domains (5) summary
    smart00294
    Location:388406
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:240303
    IGc2; Immunoglobulin C-2 Type
    cd00096
    Location:242251
    Ig; Ig strand B [structural motif]
    cd05884
    Location:120223
    IgI_2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3); member of the I-set of Ig superfamily domains
    cd07701
    Location:26121
    IgV_1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3; member of the V-set of Ig superfamily (IgSF) domains
  14. NM_153184.4NP_694854.2  cell adhesion molecule 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_694854.2

    Status: REVIEWED

    Source sequence(s)
    AC107024, AC117452, AC119726, AC119729
    Consensus CDS
    CCDS33792.1
    UniProtKB/Swiss-Prot
    Q8N3J6
    Related
    ENSP00000384193.2, ENST00000405615.2
    Conserved Domains (4) summary
    smart00294
    Location:390408
    4.1m; putative band 4.1 homologues' binding motif
    smart00408
    Location:242305
    IGc2; Immunoglobulin C-2 Type
    cd05884
    Location:143225
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:28122
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    84958989..86074429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006062.2XP_016861551.1  cell adhesion molecule 2 isoform X1

  2. XM_017006063.2XP_016861552.1  cell adhesion molecule 2 isoform X3

    Conserved Domains (5) summary
    smart00294
    Location:350368
    4.1m; putative band 4.1 homologues' binding motif
    cd05884
    Location:143225
    Ig2_Necl-3; Second immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    cd07701
    Location:28122
    Ig1_Necl-3; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule-3 (Necl-3, also known as cell adhesion molecule 2 (CADM2))
    smart00408
    Location:242305
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:241315
    IG_like; Immunoglobulin like

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654711.1 Reference GRCh38.p13 PATCHES

    Range
    174212..174894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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