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LCLAT1 lysocardiolipin acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 253558, updated on 24-Nov-2020

Summary

Official Symbol
LCLAT1provided by HGNC
Official Full Name
lysocardiolipin acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:26756
See related
Ensembl:ENSG00000172954 MIM:614241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYCAT; AGPAT8; ALCAT1; 1AGPAT8; UNQ1849; HSRG1849
Expression
Ubiquitous expression in thyroid (RPKM 4.7), duodenum (RPKM 3.7) and 25 other tissues See more
Orthologs

Genomic context

See LCLAT1 in Genome Data Viewer
Location:
2p23.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (30447241..30644225)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30670102..30867091)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723594 Neighboring gene long intergenic non-protein coding RNA 1936 Neighboring gene calpain 13 Neighboring gene uncharacterized LOC105374435

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
O-acyltransferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cardiolipin acyl-chain remodeling TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
lysocardiolipin acyltransferase 1
Names
1-AGP acyltransferase 8
1-AGPAT 8
1-acylglycerol-3-phosphate O-acyltransferase 8
acyl-CoA:lysocardiolipin acyltransferase 1
NP_001002257.1
NP_001291374.1
NP_001291375.1
NP_872357.2
XP_005264301.1
XP_005264302.1
XP_011531043.1
XP_011531044.1
XP_011531046.1
XP_016859235.1
XP_016859236.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002257.3NP_001002257.1  lysocardiolipin acyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001002257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC132154, BC146817, BX537607
    Consensus CDS
    CCDS42670.1
    UniProtKB/Swiss-Prot
    Q6UWP7
    Related
    ENSP00000368823.3, ENST00000379509.7
    Conserved Domains (3) summary
    cd07990
    Location:55248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234306
    Acyltransf_C; Acyltransferase C-terminus
  2. NM_001304445.2NP_001291374.1  lysocardiolipin acyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001291374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC073255, AC132154, AK302562, BX537607
    Consensus CDS
    CCDS42670.1
    UniProtKB/Swiss-Prot
    Q6UWP7
    UniProtKB/TrEMBL
    B4DYR5
    Conserved Domains (3) summary
    cd07990
    Location:55248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234306
    Acyltransf_C; Acyltransferase C-terminus
  3. NM_001304446.2NP_001291375.1  lysocardiolipin acyltransferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001291375.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC132154, AK297262, BX537607
    UniProtKB/TrEMBL
    B4DM26
    Conserved Domains (2) summary
    cd07990
    Location:1124
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:110182
    Acyltransf_C; Acyltransferase C-terminus
  4. NM_182551.5NP_872357.2  lysocardiolipin acyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_872357.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC132154, AY358702, BP872689, BX537607
    Consensus CDS
    CCDS1772.1
    UniProtKB/Swiss-Prot
    Q6UWP7
    Related
    ENSP00000310551.4, ENST00000309052.8
    Conserved Domains (3) summary
    cd07990
    Location:93286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272344
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    30447241..30644225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264245.3XP_005264302.1  lysocardiolipin acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_005264302.1

    UniProtKB/Swiss-Prot
    Q6UWP7
    Conserved Domains (3) summary
    cd07990
    Location:55248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234306
    Acyltransf_C; Acyltransferase C-terminus
  2. XM_005264244.1XP_005264301.1  lysocardiolipin acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005264301.1

    UniProtKB/Swiss-Prot
    Q6UWP7
    Conserved Domains (3) summary
    cd07990
    Location:93286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272344
    Acyltransf_C; Acyltransferase C-terminus
  3. XM_017003746.1XP_016859235.1  lysocardiolipin acyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6UWP7
    Conserved Domains (3) summary
    cd07990
    Location:55248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234306
    Acyltransf_C; Acyltransferase C-terminus
  4. XM_017003747.2XP_016859236.1  lysocardiolipin acyltransferase 1 isoform X4

  5. XM_011532744.3XP_011531046.1  lysocardiolipin acyltransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011531046.1

    Conserved Domains (2) summary
    cd07990
    Location:1124
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:110182
    Acyltransf_C; Acyltransferase C-terminus
  6. XM_011532741.2XP_011531043.1  lysocardiolipin acyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011531043.1

    UniProtKB/Swiss-Prot
    Q6UWP7
    Conserved Domains (3) summary
    cd07990
    Location:93286
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:45324
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:272344
    Acyltransf_C; Acyltransferase C-terminus
  7. XM_011532742.3XP_011531044.1  lysocardiolipin acyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_011531044.1

    UniProtKB/Swiss-Prot
    Q6UWP7
    Conserved Domains (3) summary
    cd07990
    Location:55248
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PRK14014
    Location:7286
    PRK14014; putative acyltransferase; Provisional
    pfam16076
    Location:234306
    Acyltransf_C; Acyltransferase C-terminus
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