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ZBTB38 zinc finger and BTB domain containing 38 [ Homo sapiens (human) ]

Gene ID: 253461, updated on 1-Jun-2020

Summary

Official Symbol
ZBTB38provided by HGNC
Official Full Name
zinc finger and BTB domain containing 38provided by HGNC
Primary source
HGNC:HGNC:26636
See related
Ensembl:ENSG00000177311 MIM:612218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIBZ; ZNF921; PPP1R171
Summary
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in endometrium (RPKM 20.7), gall bladder (RPKM 13.0) and 24 other tissues See more
Orthologs

Genomic context

See ZBTB38 in Genome Data Viewer
Location:
3q23
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141324186..141449792)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141043055..141168634)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 2-phosphoxylose phosphatase 1 Neighboring gene ribosomal protein L31 pseudogene 21 Neighboring gene PHD finger protein 5A pseudogene Neighboring gene keratin 18 pseudogene 35 Neighboring gene RAS p21 protein activator 2 Neighboring gene YWHAQ pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
NHGRI GWA Catalog
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
NHGRI GWA Catalog
Common variants in the GDF5-UQCC region are associated with variation in human height.
NHGRI GWA Catalog
Genome-wide association analysis identifies 20 loci that influence adult height.
NHGRI GWA Catalog
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
NHGRI GWA Catalog
Genome-wide Interrogation of Longitudinal FEV1 in Children with Asthma.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Identification of 15 loci influencing height in a Korean population.
NHGRI GWA Catalog
Identification of ten loci associated with height highlights new biological pathways in human growth.
NHGRI GWA Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
NHGRI GWA Catalog
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22332, FLJ31131, FLJ35036

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 38
Names
protein phosphatase 1, regulatory subunit 171

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021426.1 RefSeqGene

    Range
    4974..130580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080412.3NP_001073881.2  zinc finger and BTB domain-containing protein 38

    See identical proteins and their annotated locations for NP_001073881.2

    Status: REVIEWED

    Source sequence(s)
    AA683353, AC117383, AK025985, AK092355, AL833148, BC015444, BC051734, BC072415, DA347543, DC420906
    Consensus CDS
    CCDS43157.1
    UniProtKB/Swiss-Prot
    Q8NAP3
    UniProtKB/TrEMBL
    Q9H6F0
    Conserved Domains (5) summary
    sd00017
    Location:10121032
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:10381060
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:10251048
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:332402
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001350099.2NP_001337028.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AA683353, AC010184, BC051734
    Consensus CDS
    CCDS43157.1
    Conserved Domains (5) summary
    sd00017
    Location:10121032
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:10381060
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:10251048
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:332402
    zf-C2H2_8; C2H2-type zinc ribbon
  3. NM_001350100.2NP_001337029.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AA683353, AC010184, BC051734
    Consensus CDS
    CCDS43157.1
    Conserved Domains (5) summary
    sd00017
    Location:10121032
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:10381060
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:23122
    BTB; BTB/POZ domain
    pfam13465
    Location:10251048
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:332402
    zf-C2H2_8; C2H2-type zinc ribbon
  4. NM_001376112.1NP_001363041.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  5. NM_001376113.1NP_001363042.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  6. NM_001376114.1NP_001363043.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  7. NM_001376115.1NP_001363044.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  8. NM_001376116.1NP_001363045.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  9. NM_001376117.1NP_001363046.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  10. NM_001376118.1NP_001363047.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  11. NM_001376119.1NP_001363048.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  12. NM_001376120.1NP_001363049.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  13. NM_001376121.1NP_001363050.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  14. NM_001376122.1NP_001363051.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  15. NM_001376123.1NP_001363052.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  16. NM_001376124.1NP_001363053.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  17. NM_001376125.1NP_001363054.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  18. NM_001376126.1NP_001363055.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  19. NM_001376127.1NP_001363056.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  20. NM_001376128.1NP_001363057.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  21. NM_001376142.1NP_001363071.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  22. NM_001376143.1NP_001363072.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  23. NM_001376150.1NP_001363079.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  24. NM_001376152.1NP_001363081.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  25. NM_001376157.1NP_001363086.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  26. NM_001376158.1NP_001363087.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  27. NM_001376159.1NP_001363088.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  28. NM_001376160.1NP_001363089.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  29. NM_001376161.1NP_001363090.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  30. NM_001376162.1NP_001363091.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  31. NM_001376163.1NP_001363092.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  32. NM_001376164.1NP_001363093.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
    Related
    ENSP00000372635.5, ENST00000321464.6
  33. NM_001376165.1NP_001363094.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  34. NM_001376166.1NP_001363095.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
    Related
    ENSP00000490041.1, ENST00000637056.1
  35. NM_001376167.1NP_001363096.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  36. NM_001376168.1NP_001363097.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  37. NM_001376169.1NP_001363098.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  38. NM_001376170.1NP_001363099.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  39. NM_001376171.1NP_001363100.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  40. NM_001376172.1NP_001363101.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  41. NM_001376173.1NP_001363102.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  42. NM_001376174.1NP_001363103.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  43. NM_001376175.1NP_001363104.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  44. NM_001376176.1NP_001363105.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  45. NM_001376177.1NP_001363106.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  46. NM_001376178.1NP_001363107.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  47. NM_001376179.1NP_001363108.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
    Related
    ENSP00000426387.1, ENST00000514251.5
  48. NM_001376180.1NP_001363109.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  49. NM_001376181.1NP_001363110.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  50. NM_001376182.1NP_001363111.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  51. NM_001376183.1NP_001363112.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  52. NM_001376184.1NP_001363113.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  53. NM_001376185.1NP_001363114.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  54. NM_001376186.1NP_001363115.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  55. NM_001376187.1NP_001363116.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  56. NM_001376188.1NP_001363117.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  57. NM_001376189.1NP_001363118.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184
  58. NM_001376190.1NP_001363119.1  zinc finger and BTB domain-containing protein 38

    Status: REVIEWED

    Source sequence(s)
    AC010184

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    141324186..141449792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247256.5XP_005247313.1  zinc finger and BTB domain-containing protein 38 isoform X2

    Conserved Domains (5) summary
    smart00225
    Location:35131
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:10131033
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:10391061
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:24123
    BTB; BTB/POZ domain
    pfam13465
    Location:10261049
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152535.1: Suppressed sequence

    Description
    NM_152535.1: This RefSeq was permanently suppressed because it contains the wrong CDS, and it is entirely UTR sequence.
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