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IPMK inositol polyphosphate multikinase [ Homo sapiens (human) ]

Gene ID: 253430, updated on 9-Jun-2025
Official Symbol
IPMKprovided by HGNC
Official Full Name
inositol polyphosphate multikinaseprovided by HGNC
Primary source
HGNC:HGNC:20739
See related
Ensembl:ENSG00000151151 MIM:609851; AllianceGenome:HGNC:20739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in colon (RPKM 5.2), small intestine (RPKM 4.9) and 25 other tissues See more
Orthologs
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See IPMK in Genome Data Viewer
Location:
10q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (58191517..58267894, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (59045622..59122002, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (59951278..60027654, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902547 Neighboring gene mitochondrial ribosomal protein S35 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:59810283-59810783 Neighboring gene NANOG hESC enhancer GRCh37_chr10:59893686-59894187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:59970095-59970595 Neighboring gene small nucleolar RNA U13 Neighboring gene TPT1 pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 9892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:60028628-60029184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2377 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene uncharacterized LOC112268068

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables flavonoid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol phosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol-1,4,5-trisphosphate 6-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
involved_in inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
NP_689416.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152230.5NP_689416.1  inositol polyphosphate multikinase

    See identical proteins and their annotated locations for NP_689416.1

    Status: REVIEWED

    Source sequence(s)
    AC026884, BC065709
    Consensus CDS
    CCDS7250.1
    UniProtKB/Swiss-Prot
    Q8NFU5
    Related
    ENSP00000363046.3, ENST00000373935.4
    Conserved Domains (1) summary
    pfam03770
    Location:127411
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    58191517..58267894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    59045622..59122002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)