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IPMK inositol polyphosphate multikinase [ Homo sapiens (human) ]

Gene ID: 253430, updated on 8-Jul-2021

Summary

Official Symbol
IPMKprovided by HGNC
Official Full Name
inositol polyphosphate multikinaseprovided by HGNC
Primary source
HGNC:HGNC:20739
See related
Ensembl:ENSG00000151151 MIM:609851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in colon (RPKM 5.2), small intestine (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See IPMK in Genome Data Viewer
Location:
10q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (58191517..58269961, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (59951278..60027654, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378314 Neighboring gene mitochondrial ribosomal protein S35 pseudogene 3 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC112268068 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene Sharpr-MPRA regulatory region 7957 Neighboring gene ubiquitin conjugating enzyme E2 D1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of coronary artery calcification among African Americans, a meta-analysis.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables flavonoid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol tetrakisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol tetrakisphosphate 5-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol tetrakisphosphate 6-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inositol tetrakisphosphate 6-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol tetrakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inositol-1,4,5-trisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
enables inositol-1,4,5-trisphosphate 6-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
involved_in inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
NP_689416.1
XP_011537867.1
XP_016871502.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152230.5NP_689416.1  inositol polyphosphate multikinase

    See identical proteins and their annotated locations for NP_689416.1

    Status: REVIEWED

    Source sequence(s)
    AC026884, BC065709
    Consensus CDS
    CCDS7250.1
    UniProtKB/Swiss-Prot
    Q8NFU5
    Related
    ENSP00000363046.3, ENST00000373935.4
    Conserved Domains (1) summary
    pfam03770
    Location:127411
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    58191517..58269961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016013.2XP_016871502.1  inositol polyphosphate multikinase isoform X2

  2. XM_011539565.3XP_011537867.1  inositol polyphosphate multikinase isoform X1

    Conserved Domains (1) summary
    pfam03770
    Location:130414
    IPK; Inositol polyphosphate kinase
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