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IPMK inositol polyphosphate multikinase [ Homo sapiens (human) ]

Gene ID: 253430, updated on 12-Oct-2019

Summary

Official Symbol
IPMKprovided by HGNC
Official Full Name
inositol polyphosphate multikinaseprovided by HGNC
Primary source
HGNC:HGNC:20739
See related
Ensembl:ENSG00000151151 MIM:609851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in colon (RPKM 5.2), small intestine (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See IPMK in Genome Data Viewer
Location:
10q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (58191517..58269961, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (59951278..60027694, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378314 Neighboring gene mitochondrial ribosomal protein S35 pseudogene 3 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 10 Neighboring gene uncharacterized LOC112268068 Neighboring gene CDGSH iron sulfur domain 1 Neighboring gene Sharpr-MPRA regulatory region 7957 Neighboring gene ubiquitin conjugating enzyme E2 D1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetics of coronary artery calcification among African Americans, a meta-analysis.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
flavonoid binding IDA
Inferred from Direct Assay
more info
PubMed 
inositol tetrakisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
inositol tetrakisphosphate 5-kinase activity TAS
Traceable Author Statement
more info
 
inositol tetrakisphosphate 6-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
inositol tetrakisphosphate 6-kinase activity TAS
Traceable Author Statement
more info
 
inositol-1,4,5-trisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol-1,4,5-trisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
inositol-1,4,5-trisphosphate 6-kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol trisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inositol polyphosphate multikinase
Names
inositol 1,3,4,6-tetrakisphosphate 5-kinase
NP_689416.1
XP_011537867.1
XP_016871502.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152230.5NP_689416.1  inositol polyphosphate multikinase

    See identical proteins and their annotated locations for NP_689416.1

    Status: REVIEWED

    Source sequence(s)
    AC026884, BC065709
    Consensus CDS
    CCDS7250.1
    UniProtKB/Swiss-Prot
    Q8NFU5
    Related
    ENSP00000363046.3, ENST00000373935.4
    Conserved Domains (1) summary
    pfam03770
    Location:127411
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    58191517..58269961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016013.2XP_016871502.1  inositol polyphosphate multikinase isoform X2

  2. XM_011539565.3XP_011537867.1  inositol polyphosphate multikinase isoform X1

    Conserved Domains (1) summary
    pfam03770
    Location:130414
    IPK; Inositol polyphosphate kinase
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