Format

Send to:

Choose Destination

FYN FYN proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2534, updated on 5-Jul-2020

Summary

Official Symbol
FYNprovided by HGNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:4037
See related
Ensembl:ENSG00000010810 MIM:137025
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLK; SYN; p59-FYN
Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 36.8), lymph node (RPKM 29.8) and 23 other tissues See more
Orthologs

Genomic context

See FYN in Genome Data Viewer
Location:
6q21
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (111660332..111873452, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111981535..112194655, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TRAF3IP2 antisense RNA 1 Neighboring gene TRAF3 interacting protein 2 Neighboring gene TRAF3IP2 eExon liver enhancer Neighboring gene uncharacterized LOC105377944 Neighboring gene uncharacterized LOC105377945 Neighboring gene uncharacterized LOC102724646 Neighboring gene long intergenic non-protein coding RNA 2527 Neighboring gene uncharacterized LOC105377947

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tyrosine kinase Fyn-mediated phosphorylation of IFITM3 at position Y20 induces localization of IFITM3 at the endocytic compartments, which impairs inhibition of Env-mediated entry by IFITM3 delta(1-21) mutant PubMed
env Interaction of HIV-1 gp120 with CD4 leads to increased levels of phosphorylation of the src-family Lck and Fyn protein tyrosine kinases and enhancement of their activities PubMed
Envelope surface glycoprotein gp160, precursor env Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 and gp41-induced cell killing is accompanied by tyrosine phosphorylation and activation of the CD4-associated p56(Lck) kinase, and by activation of a second member of the scr family of protein tyrosine kinases, p59(fyn) kinase PubMed
Nef nef HIV-1 Nef binds to the SH3 domain of Fyn through its proline-rich (PXXP) motifs between amino acid residues 65 and 82; this binding enhances viral replication but not down-regulation of CD4 PubMed
nef The single amino acid residue number 96 in the SH3 domain of Fyn regulates its affinity and specificity in binding to HIV-1 Nef PubMed
nef Crystal structure studies reveal the conserved PXXP sequence motif of HIV-1 Nef is part of a polyproline type II helix that is required for Nef binding to the SH3 domain of Fyn PubMed
Pr55(Gag) gag Fyn enhances HIV-1 Gag assembly and release in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CD4 receptor binding IEA
Inferred from Electronic Annotation
more info
 
CD8 receptor binding IEA
Inferred from Electronic Annotation
more info
 
T cell receptor binding IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
peptide hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding TAS
Traceable Author Statement
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
type 5 metabotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
calcium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to L-glutamate ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to amyloid-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glycine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dendritic spine maintenance TAS
Traceable Author Statement
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
feeding behavior TAS
Traceable Author Statement
more info
PubMed 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
heart process IGI
Inferred from Genetic Interaction
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
learning TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced cell death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein localization to membrane TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
regulation of glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to singlet oxygen ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
actin filament IEA
Inferred from Electronic Annotation
more info
 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft TAS
Traceable Author Statement
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
perinuclear endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Fyn
Names
FYN oncogene related to SRC, FGR, YES
OKT3-induced calcium influx regulator
c-syn protooncogene
proto-oncogene Syn
proto-oncogene c-Fyn
src-like kinase
src/yes-related novel
tyrosine kinase p59fyn(T)
NP_001357458.1
NP_002028.1
NP_694592.1
NP_694593.1
XP_005266949.1
XP_016866139.1
XP_016866140.1
XP_016866141.1
XP_016866142.1
XP_016866144.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370529.1NP_001357458.1  tyrosine-protein kinase Fyn isoform a

    Status: REVIEWED

    Source sequence(s)
    AL109916, Z97989
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  2. NM_002037.5NP_002028.1  tyrosine-protein kinase Fyn isoform a

    See identical proteins and their annotated locations for NP_002028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BP391373, DA570412, M14333, Z97989
    Consensus CDS
    CCDS5094.1
    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000346671.3, ENST00000354650.7
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  3. NM_153047.4NP_694592.1  tyrosine-protein kinase Fyn isoform b

    See identical proteins and their annotated locations for NP_694592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate in-frame exon but includes a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AL109916, AL158035, Z97989
    Consensus CDS
    CCDS5095.1
    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000357671.3, ENST00000368682.7
    Conserved Domains (3) summary
    cd10368
    Location:145245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  4. NM_153048.3NP_694593.1  tyrosine-protein kinase Fyn isoform c

    See identical proteins and their annotated locations for NP_694593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    BC032496, BP391373, DA815564, Z97989
    Consensus CDS
    CCDS5096.1
    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000229471.4, ENST00000229471.8
    Conserved Domains (3) summary
    cd10368
    Location:145245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:231467
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    111660332..111873452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266892.4XP_005266949.1  tyrosine-protein kinase Fyn isoform X3

    See identical proteins and their annotated locations for XP_005266949.1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (3) summary
    cd10368
    Location:145245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:231467
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017010651.1XP_016866140.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  3. XM_017010650.1XP_016866139.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/Swiss-Prot
    P06241
    Related
    ENSP00000357656.2, ENST00000368667.6
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  4. XM_017010653.1XP_016866142.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  5. XM_017010652.1XP_016866141.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/Swiss-Prot
    P06241
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
  6. XM_017010655.2XP_016866144.1  tyrosine-protein kinase Fyn isoform X4

    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cl21453
    Location:261288
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001242779.1: Suppressed sequence

    Description
    NM_001242779.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center