Egf epidermal growth factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Egfprovided by RGD
Full Name: epidermal growth factorprovided by RGD
Primary source: RGD:2542
See related: Ensembl:ENSRNOG00000053979 AllianceGenome:RGD:2542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 3383.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (220893660..220976331, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (218219408..218302359, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (68820616..68895537)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: A possible role of EGF.
Title: Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: A possible role of EGF.
EGF promotes DKK1 transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3.
Title: EGF promotes DKK1 transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3.
Epidermal growth factor regulation by autophagy-mediated lncRNA H19 in murine intestinal tract after severe burn.
Title: Epidermal growth factor regulation by autophagy-mediated lncRNA H19 in murine intestinal tract after severe burn.
Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.
Title: Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.
The expression of EGF was elevated on the first day after tympanic membrane (TM)injury, not reaching statistical significance, and then returned to the level observed in the control TM.
Title: Enhanced expression of hepatocyte growth factor in the healing of experimental acute tympanic membrane perforation.
A decrease in EGF levels may contribute to the formation of visceral hypersensitivity through downregulation of SERT-mediated 5-HT uptake into enterocytes.
Title: Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome.
The role of EGF on apoptosis, cell proliferation, oxidative stress and antioxidant system in intestinal injury induced by ischemia/reperfusion in rats.
Title: The role of epidermal growth factor in prevention of oxidative injury and apoptosis induced by intestinal ischemia/reperfusion in rats.
results indentify EGF signalling as a robust vasculogenic inductive pathway for ATMCs, leading to their transdifferentiation into functional VSMC-like cells.
Title: EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation.
Epidermal growth factor and erythropoietin infusion accelerate functional recovery in combination with rehabilitation.
Title: Epidermal growth factor and erythropoietin infusion accelerate functional recovery in combination with rehabilitation.
these findings indicate that cortical EGF levels decrease with a high-salt diet in salt-sensitive rats, promoting ENaC-mediated Na(+) reabsorption in the collecting duct and the development of hypertension.
Title: Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (55)

General gene information

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Markers

RH133380 (e-PCR)
- UniSTS:216663

RH94666 (e-PCR)
- UniSTS:119913

D2Rat61 (e-PCR)
- UniSTS:118711

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERBB2-EGFR signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
involved_in system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-epidermal growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012842.2 → NP_036974.2 pro-epidermal growth factor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A0G2KAF5, Q6P6T8

Related

ENSRNOP00000075379.3, ENSRNOT00000089504.3

Conserved Domains (7) summary

PHA03099
Location:974 → 1016

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

smart00135
Location:548 → 590

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:873 → 913

EGF_CA; Calcium-binding EGF-like domain

pfam12662
Location:339 → 360

cEGF; Complement Clr-like EGF-like

pfam12947
Location:919 → 943

EGF_3; EGF domain

pfam14670
Location:361 → 396

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl21504
Location:839 → 871

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

220893660..220976331 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281339.1 → XP_063137409.1 pro-epidermal growth factor isoform X1

UniProtKB/TrEMBL

A0A1W2Q6M4, Q6P6T8
XM_039101781.2 → XP_038957709.1 pro-epidermal growth factor isoform X2

Conserved Domains (3) summary

smart00135
Location:548 → 590

LY; Low-density lipoprotein-receptor YWTD domain

pfam12662
Location:339 → 360

cEGF; Complement Clr-like EGF-like

pfam14670
Location:361 → 396

FXa_inhibition; Coagulation Factor Xa inhibitory site