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FNDC5 fibronectin type III domain containing 5 [ Homo sapiens (human) ]

Gene ID: 252995, updated on 8-Jul-2018
Official Symbol
FNDC5provided by HGNC
Official Full Name
fibronectin type III domain containing 5provided by HGNC
Primary source
HGNC:HGNC:20240
See related
Ensembl:ENSG00000160097 MIM:611906; Vega:OTTHUMG00000004015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRCP2; irisin
Summary
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Biased expression in heart (RPKM 13.5), liver (RPKM 8.6) and 10 other tissues See more
Orthologs
See FNDC5 in Genome Data Viewer
Location:
1p35.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (32862268..32872492, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33327869..33338093, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene KIAA1522 Neighboring gene tyrosyl-tRNA synthetase Neighboring gene S100P binding protein Neighboring gene uncharacterized LOC105378631 Neighboring gene hippocalcin Neighboring gene transmembrane protein 54

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of brown fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
fibronectin type III domain-containing protein 5
Names
fibronectin type III repeat-containing protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171940.1NP_001165411.2  fibronectin type III domain-containing protein 5 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001165411.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation from an alternate "AUA" start codon that is conserved as an "AUG" start codon in orthologs. The encoded isoform (3) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    BC033123, BE502835, BX537781
    UniProtKB/Swiss-Prot
    Q8NAU1
    Conserved Domains (2) summary
    cd00063
    Location:34124
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16066
    Location:149172
    DUF4808; Domain of unknown function (DUF4808)
  2. NM_001171941.2NP_001165412.1  fibronectin type III domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001165412.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AC114493, BC033123, BC062297, CV815003, DA393478
    Consensus CDS
    CCDS65483.1
    UniProtKB/Swiss-Prot
    Q8NAU1
    Related
    ENSP00000476320.1, OTTHUMP00000274499, ENST00000496770.1, OTTHUMT00000011472
    Conserved Domains (2) summary
    cd00063
    Location:549
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16066
    Location:76128
    DUF4808; Domain of unknown function (DUF4808)
  3. NM_153756.2NP_715637.2  fibronectin type III domain-containing protein 5 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_715637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation from an alternate "AUA" start codon that is conserved as an "AUG" start codon in orthologs. The encoded isoform (2) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK092102, BC033123, BE502835
    Consensus CDS
    CCDS369.2
    UniProtKB/Swiss-Prot
    Q8NAU1
    Related
    ENSP00000362570.4, OTTHUMP00000004134, ENST00000373471.7, OTTHUMT00000011467
    Conserved Domains (2) summary
    cd00063
    Location:34124
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam16066
    Location:151203
    DUF4808; Domain of unknown function (DUF4808)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    32862268..32872492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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