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Myh8 myosin heavy chain 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 252942, updated on 12-Jan-2022

Summary

Official Symbol
Myh8provided by RGD
Official Full Name
myosin heavy chain 8provided by RGD
Primary source
RGD:620356
See related
Ensembl:ENSRNOG00000068010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process; muscle filament sliding; and skeletal muscle contraction. Predicted to be located in cytoplasm. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis type 7. Orthologous to human MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward (RPKM 11166.8) See more
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Genomic context

See Myh8 in Genome Data Viewer
Location:
10q24
Exon count:
39
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51963510..51993103)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53818818..53848490)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 1 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 13 Neighboring gene up-regulated during skeletal muscle growth protein 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in developmental process IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle filament sliding IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle filament sliding ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
part_of myosin complex ISO
Inferred from Sequence Orthology
more info
 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin-8
Names
myHC-perinatal
myosin heavy chain, skeletal muscle, perinatal
myosin, heavy chain 8, skeletal muscle, perinatal
myosin, heavy polypeptide 8, skeletal muscle, perinatal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100485.1NP_001093955.1  myosin-8

    See identical proteins and their annotated locations for NP_001093955.1

    Status: VALIDATED

    Source sequence(s)
    CH473948
    Related
    ENSRNOP00000077580.1, ENSRNOT00000105953.1
    Conserved Domains (8) summary
    cl22853
    Location:102769
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:90769
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8491926
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3875
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam06273
    Location:10421099
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    pfam07851
    Location:14561584
    TMPIT; TMPIT-like protein
    cl19764
    Location:13751510
    COG6; Conserved oligomeric complex COG6
    cl23720
    Location:9641097
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    51963510..51993103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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