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Acadl acyl-CoA dehydrogenase, long chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 25287, updated on 9-Sep-2018

Summary

Official Symbol
Acadlprovided by RGD
Official Full Name
acyl-CoA dehydrogenase, long chainprovided by RGD
Primary source
RGD:2011
See related
Ensembl:ENSRNOG00000012966
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LCAD; ACOADA
Summary
catalyzes the alpha, beta-dehydrogenation of acyl-CoA esters in fatty acid metabolism [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 1009.8), Adrenal (RPKM 481.5) and 7 other tissues See more
Orthologs

Genomic context

See Acadl in Genome Data Viewer
Location:
9q32
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73833368..73871857, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (73434371..73472895)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene ribulose-5-phosphate-3-epimerase Neighboring gene myosin, light chain 1 Neighboring gene similar to D19Bwg1357e protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
long-chain-acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain-acyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain-acyl-CoA dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
palmitoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carnitine catabolic process ISO
Inferred from Sequence Orthology
more info
 
carnitine metabolic process, CoA-linked IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carnitine metabolic process, CoA-linked ISO
Inferred from Sequence Orthology
more info
 
cellular lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
Inferred from Sequence Orthology
more info
 
fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to cold ISO
Inferred from Sequence Orthology
more info
 
temperature homeostasis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
long-chain specific acyl-CoA dehydrogenase, mitochondrial
Names
Acyl Coenzyme A dehydrogenase, long chain
LCAD long chain acyl-CoA dehydrogenase
acetyl-Coenzyme A dehydrogenase, long-chain
acyl-Coenzyme A dehydrogenase, long-chain
long-chain acyl-CoA dehydrogenase
NP_036951.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012819.1NP_036951.1  long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036951.1

    Status: PROVISIONAL

    Source sequence(s)
    L11276
    UniProtKB/Swiss-Prot
    P15650
    Related
    ENSRNOP00000017686.4, ENSRNOT00000017686.7
    Conserved Domains (2) summary
    cd01160
    Location:56427
    LCAD; Long chain acyl-CoA dehydrogenase
    COG1960
    Location:53427
    CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    73833368..73871857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    65813263..65851320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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