U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dusp15 dual specificity phosphatase-like 15 [ Mus musculus (house mouse) ]

Gene ID: 252864, updated on 12-Feb-2023

Summary

Go to the top of the page Help
Official Symbol
Dusp15provided by MGI
Official Full Name
dual specificity phosphatase-like 15provided by MGI
Primary source
MGI:MGI:1934928
See related
Ensembl:ENSMUSG00000042662 AllianceGenome:MGI:1934928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
T-DSP10; LMW-DSP10
Summary
Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Involved in regulation of oligodendrocyte differentiation. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in peripheral nervous system and spinal cord. Orthologous to human DUSP15 (dual specificity phosphatase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 37.1), cerebellum adult (RPKM 10.8) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dusp15 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152782915..152794200, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152940995..152952400, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle Neighboring gene forkhead box S1 Neighboring gene tubulin tyrosine ligase-like family, member 9 Neighboring gene predicted gene 14199 Neighboring gene p53 and DNA damage regulated 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact. Rawlings-Mortimer F, et al. PLoS One, 2023. PMID 36730342, Free PMC Article
  2. Dual specificity phosphatase 15 regulates Erk activation in Schwann cells. Rodríguez-Molina JF, et al. J Neurochem, 2017 Feb. PMID 27891578, Free PMC Article
  3. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. Schmidt F, et al. PLoS One, 2012. PMID 22792334, Free PMC Article
  4. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. Alonso A, et al. J Biol Chem, 2004 Jul 30. PMID 15138252
  5. The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Muth KN, et al. Glia, 2016 Dec. PMID 27532821

See all (24) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.
    Title: DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.
  2. Dusp15 is necessary for full activation of Erk 1/2 phosphorylation in Schwann cells.
    Title: Dual specificity phosphatase 15 regulates Erk activation in Schwann cells.
  3. VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
    Title: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 15
Names
dual specificity protein phosphatase T-DSP10
NP_001152848.1
NP_665687.1
XP_006499605.1
XP_011237861.1
XP_011237862.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159376.1 → NP_001152848.1  dual specificity protein phosphatase 15 isoform 1

    See identical proteins and their annotated locations for NP_001152848.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AL833801
    Consensus CDS
    CCDS50754.1
    UniProtKB/Swiss-Prot
    Q14AH2, Q8R4V2
    Related
    ENSMUSP00000123090.2, ENSMUST00000123121.9
    Conserved Domains (1) summary
    cd00127
    Location:4 → 138
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. NM_145744.2 → NP_665687.1  dual specificity protein phosphatase 15 isoform 2

    See identical proteins and their annotated locations for NP_665687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL833801
    Consensus CDS
    CCDS16902.1
    UniProtKB/Swiss-Prot
    Q8R4V2
    UniProtKB/TrEMBL
    A0A8C6G6H9
    Related
    ENSMUSP00000045815.6, ENSMUST00000037715.7
    Conserved Domains (1) summary
    cl21483
    Location:4 → 101
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152782915..152794200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239560.4 → XP_011237862.1  dual specificity protein phosphatase 15 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:73 → 135
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_011239559.4 → XP_011237861.1  dual specificity protein phosphatase 15 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:80 → 142
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_006499542.5 → XP_006499605.1  dual specificity protein phosphatase 15 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 43
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_003952999.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4V2.3 GenPept UniProtKB/Swiss-Prot:Q8R4V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous