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TMEM9 transmembrane protein 9 [ Homo sapiens (human) ]

Gene ID: 252839, updated on 15-Jun-2019

Summary

Official Symbol
TMEM9provided by HGNC
Official Full Name
transmembrane protein 9provided by HGNC
Primary source
HGNC:HGNC:18823
See related
Ensembl:ENSG00000116857 MIM:616877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DERM4; TMEM9A
Expression
Ubiquitous expression in brain (RPKM 25.4), thyroid (RPKM 25.3) and 25 other tissues See more
Orthologs

Genomic context

See TMEM9 in Genome Data Viewer
Location:
1q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (201134771..201171625, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201103900..201140710, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929305 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene immunoglobulin like and fibronectin type III domain containing 1 Neighboring gene plakophilin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 9
Names
dermal papilla-derived protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288564.1NP_001275493.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI201238, AK054883, DA141558
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Related
    ENSP00000356302.2, ENST00000367333.6
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  2. NM_001288565.2NP_001275494.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275494.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI201238, AK054883, AK091726, CX751563, DA160051, DA364005
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Related
    ENSP00000356299.1, ENST00000367330.6
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  3. NM_001288566.1NP_001275495.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI201238, AK054883, DA364005, DB031447
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  4. NM_001288567.1NP_001275496.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275496.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI201238, AK054883, AL516746, DA160051, DA364005
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Related
    ENSP00000476893.1, ENST00000485839.6
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  5. NM_001288568.1NP_001275497.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AI201238, AK054883, BE782946, DA364005, DA625212
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  6. NM_001288569.1NP_001275498.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_001275498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AF151020, AI201238, AK054883, DA364005
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9
  7. NM_001288570.1NP_001275499.1  transmembrane protein 9 isoform b precursor

    See identical proteins and their annotated locations for NP_001275499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is longer, compared to isoform a.
    Source sequence(s)
    AI201238, AK054883, DA364005
    Consensus CDS
    CCDS73001.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    B1ALM5
    Related
    ENSP00000356301.1, ENST00000367332.5
    Conserved Domains (1) summary
    pfam05434
    Location:47185
    Tmemb_9; TMEM9
  8. NM_001288571.1NP_001275500.1  transmembrane protein 9 isoform c precursor

    See identical proteins and their annotated locations for NP_001275500.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is longer, compared to isoform a.
    Source sequence(s)
    AI201238, AK054883, AK303843, AL139159, DA364005
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    B4E1H4
    Conserved Domains (1) summary
    pfam05434
    Location:69207
    Tmemb_9; TMEM9
  9. NM_016456.4NP_057540.1  transmembrane protein 9 isoform a precursor

    See identical proteins and their annotated locations for NP_057540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a). Variants 1-7 encode the same isoform.
    Source sequence(s)
    AF151020, AI201238, AK054883, DA364005
    Consensus CDS
    CCDS1408.1
    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    A0A024R967
    Related
    ENSP00000356303.5, ENST00000367334.9
    Conserved Domains (1) summary
    pfam05434
    Location:44182
    Tmemb_9; TMEM9

RNA

  1. NR_109920.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI201238, AK054883, BM928361, DA364005
  2. NR_109921.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate 5'-terminal exon structure, and an alternate splice site at an internal exon, compared ot variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI201238, AK054883, BX337142, CX751563, DA364005, DA625212

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    201134771..201171625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509386.2XP_011507688.1  transmembrane protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011507688.1

    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    B1ALM5
    Conserved Domains (1) summary
    pfam05434
    Location:47185
    Tmemb_9; TMEM9
  2. XM_011509385.2XP_011507687.1  transmembrane protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011507687.1

    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    B1ALM5
    Conserved Domains (1) summary
    pfam05434
    Location:47185
    Tmemb_9; TMEM9
  3. XM_011509387.2XP_011507689.1  transmembrane protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011507689.1

    UniProtKB/Swiss-Prot
    Q9P0T7
    UniProtKB/TrEMBL
    B1ALM5
    Conserved Domains (1) summary
    pfam05434
    Location:47185
    Tmemb_9; TMEM9
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