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Nup153 nucleoporin 153 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25281, updated on 12-Aug-2018

Summary

Official Symbol
Nup153provided by RGD
Official Full Name
nucleoporin 153provided by RGD
Primary source
RGD:3216
See related
Ensembl:ENSRNOG00000001456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NUCZINK
Summary
nuclear pore complex protein; may act to to gate transcribable genes to nuclear pore complexes [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Thymus (RPKM 242.3), Spleen (RPKM 214.3) and 9 other tissues See more
Orthologs

Genomic context

See Nup153 in Genome Data Viewer
Location:
17p14
Exon count:
22
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18358712..18411368)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (19523818..19576545, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene kinesin family member 13A Neighboring gene ribosomal protein L27-like Neighboring gene family with sequence similarity 8, member A1 Neighboring gene cyclase associated actin cytoskeleton regulatory protein 2 Neighboring gene uncharacterized LOC108353127

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
PubMed 
porin activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein membrane anchor IEA
Inferred from Electronic Annotation
more info
 
protein membrane anchor ISO
Inferred from Sequence Orthology
more info
 
protein membrane anchor ISS
Inferred from Sequence or Structural Similarity
more info
 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
structural constituent of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RNA export from nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of RNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear pore complex assembly IEA
Inferred from Electronic Annotation
more info
 
nuclear pore complex assembly ISO
Inferred from Sequence Orthology
more info
 
nuclear pore complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
annulate lamellae IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inclusion body IEA
Inferred from Electronic Annotation
more info
 
nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nuclear periphery IEA
Inferred from Electronic Annotation
more info
 
nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
nuclear periphery ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore nuclear basket IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IEA
Inferred from Electronic Annotation
more info
 
nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasmic side of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
pore complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear pore complex protein Nup153
Names
153 kDa nucleoporin
nucleoporin 153kD
nucleoporin Nup153

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100470.1NP_001093940.1  nuclear pore complex protein Nup153

    See identical proteins and their annotated locations for NP_001093940.1

    Status: VALIDATED

    Source sequence(s)
    AA818240, CO574678, CV117688, L06821
    UniProtKB/TrEMBL
    G3V662
    Related
    ENSRNOP00000001979.4, ENSRNOT00000001979.5
    Conserved Domains (4) summary
    sd00025
    Location:662681
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:722750
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:114629
    Nup153; Nucleoporin Nup153-like
    pfam10599
    Location:13781468
    Nup_retrotrp_bd; Retro-transposon transporting motif

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    18358712..18411368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600457.1XP_017455946.1  nuclear pore complex protein Nup153 isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    17680974..17733501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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