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Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25275, updated on 30-Sep-2021

Summary

Official Symbol
Cnpprovided by RGD
Official Full Name
2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by RGD
Primary source
RGD:2368
See related
EnsemblRapid:ENSRNOG00000017496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CNPF; CNPI; Cnp1; CNPII
Summary
microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1563.2), Spleen (RPKM 490.2) and 6 other tissues See more
Orthologs
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Genomic context

See Cnp in Genome Data Viewer
Location:
10q31
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85511164..85517723)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88490798..88497357)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene NFKB inhibitor interacting Ras-like 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene zinc finger protein 385C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Names
CNPase
NP_036941.1
XP_006247322.1
XP_006247323.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012809.2NP_036941.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

    See identical proteins and their annotated locations for NP_036941.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098066
    UniProtKB/Swiss-Prot
    P13233
    Related
    ENSRNOP00000080276.1, ENSRNOT00000103289.1
    Conserved Domains (3) summary
    pfam05881
    Location:186398
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:52165
    AAA_33; AAA domain
    cl17190
    Location:51176
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    85511164..85517723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247261.4XP_006247323.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

    See identical proteins and their annotated locations for XP_006247323.1

    UniProtKB/TrEMBL
    A0A097BVJ5
    Conserved Domains (2) summary
    pfam05881
    Location:165378
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:32145
    AAA_33; AAA domain
  2. XM_006247260.4XP_006247322.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

    See identical proteins and their annotated locations for XP_006247322.1

    UniProtKB/TrEMBL
    A0A097BVJ5
    Related
    ENSRNOP00000077498.1, ENSRNOT00000111402.1
    Conserved Domains (2) summary
    pfam05881
    Location:165378
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:32145
    AAA_33; AAA domain
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