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Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25275, updated on 9-Dec-2018

Summary

Official Symbol
Cnpprovided by RGD
Official Full Name
2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by RGD
Primary source
RGD:2368
See related
Ensembl:ENSRNOG00000017496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CNPF; CNPI; Cnp1; CNPII
Summary
microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1563.2), Spleen (RPKM 490.2) and 6 other tissues See more
Orthologs

Genomic context

See Cnp in Genome Data Viewer
Location:
10q31
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88490798..88497357)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (88284045..88290604)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene NFKB inhibitor interacting Ras-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity TAS
Traceable Author Statement
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
cyclic nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cyclic nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEP
Inferred from Expression Pattern
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
myelin sheath abaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Names
CNPase
NP_036941.1
XP_006247322.1
XP_006247323.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012809.2NP_036941.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

    See identical proteins and their annotated locations for NP_036941.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098066
    UniProtKB/Swiss-Prot
    P13233
    Related
    ENSRNOP00000023875.3, ENSRNOT00000023872.4
    Conserved Domains (3) summary
    pfam05881
    Location:186398
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:52165
    AAA_33; AAA domain
    cl17190
    Location:51176
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    88490798..88497357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247261.3XP_006247323.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

    See identical proteins and their annotated locations for XP_006247323.1

    UniProtKB/TrEMBL
    A0A097BVJ5
    Conserved Domains (3) summary
    pfam05881
    Location:166378
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:32145
    AAA_33; AAA domain
    cl17190
    Location:31156
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_006247260.3XP_006247322.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1

    See identical proteins and their annotated locations for XP_006247322.1

    UniProtKB/TrEMBL
    A0A097BVJ5
    Conserved Domains (3) summary
    pfam05881
    Location:166378
    CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)
    pfam13671
    Location:32145
    AAA_33; AAA domain
    cl17190
    Location:31156
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    84227529..84234088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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