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Smo smoothened, frizzled class receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25273, updated on 3-Feb-2019

Summary

Official Symbol
Smoprovided by RGD
Official Full Name
smoothened, frizzled class receptorprovided by RGD
Primary source
RGD:3726
See related
Ensembl:ENSRNOG00000008332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Smoh
Summary
may act as a signaling component of the Patched (Ptch) signaling pathway [RGD, Feb 2006]
Expression
Biased expression in Uterus (RPKM 82.7), Kidney (RPKM 58.7) and 9 other tissues See more
Orthologs

Genomic context

See Smo in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57019941..57041779)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (56787102..56809935)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene tetraspanin 33 Neighboring gene adenosylhomocysteinase-like 2 Neighboring gene 60S ribosomal protein L19 pseudogene Neighboring gene striatin interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Activation of SMO, organism-specific biosystem (from REACTOME)
    Activation of SMO, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystem
    GPCRs, Other
  • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'off' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'on' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
  • Hedgehog signaling, organism-specific biosystem (from KEGG)
    Hedgehog signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hedgehog signaling, conserved biosystem (from KEGG)
    Hedgehog signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
patched binding IEA
Inferred from Electronic Annotation
more info
 
patched binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
 
astrocyte activation IEA
Inferred from Electronic Annotation
more info
 
astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development ISO
Inferred from Sequence Orthology
more info
 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell fate specification ISO
Inferred from Sequence Orthology
more info
 
cellular response to cholesterol IEA
Inferred from Electronic Annotation
more info
 
cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system development ISO
Inferred from Sequence Orthology
more info
 
central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
cerebellar cortex morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
commissural neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
detection of cell density by contact stimulus involved in contact inhibition IEA
Inferred from Electronic Annotation
more info
 
detection of cell density by contact stimulus involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
determination of left/right asymmetry in lateral mesoderm IEA
Inferred from Electronic Annotation
more info
 
determination of left/right asymmetry in lateral mesoderm ISO
Inferred from Sequence Orthology
more info
 
determination of left/right asymmetry in lateral mesoderm ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
 
developmental growth ISO
Inferred from Sequence Orthology
more info
 
digestive tract development ISO
Inferred from Sequence Orthology
more info
 
dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
 
dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
embryonic organ development ISO
Inferred from Sequence Orthology
more info
 
epithelial-mesenchymal cell signaling IEA
Inferred from Electronic Annotation
more info
 
epithelial-mesenchymal cell signaling ISO
Inferred from Sequence Orthology
more info
 
facial nerve development IEP
Inferred from Expression Pattern
more info
PubMed 
forebrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
forebrain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
forebrain morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
 
heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
left/right axis specification ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
mesenchymal to epithelial transition involved in metanephric renal vesicle formation IEA
Inferred from Electronic Annotation
more info
 
mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISO
Inferred from Sequence Orthology
more info
 
mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
midgut development IEA
Inferred from Electronic Annotation
more info
 
midgut development ISO
Inferred from Sequence Orthology
more info
 
midgut development ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
myoblast migration IEA
Inferred from Electronic Annotation
more info
 
myoblast migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neuron projection regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
ossification ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoblast proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
pancreas morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pancreas morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pattern specification process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hh target transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hh target transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hh target transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
regulation of stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
renal system development ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
smoothened signaling pathway involved in ventral spinal cord patterning IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway involved in ventral spinal cord patterning ISO
Inferred from Sequence Orthology
more info
 
somite development IEA
Inferred from Electronic Annotation
more info
 
somite development ISO
Inferred from Sequence Orthology
more info
 
somite development ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
thalamus development ISO
Inferred from Sequence Orthology
more info
 
type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
ventral midline determination IEA
Inferred from Electronic Annotation
more info
 
ventral midline determination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
caveola IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
ciliary membrane IEA
Inferred from Electronic Annotation
more info
 
ciliary membrane ISO
Inferred from Sequence Orthology
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium ISO
Inferred from Sequence Orthology
more info
 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
smoothened homolog
Names
smoothened, frizzled family receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012807.1NP_036939.1  smoothened homolog precursor

    See identical proteins and their annotated locations for NP_036939.1

    Status: PROVISIONAL

    Source sequence(s)
    U84402
    UniProtKB/Swiss-Prot
    P97698
    Related
    ENSRNOP00000011356.1, ENSRNOT00000011356.3
    Conserved Domains (2) summary
    cd07451
    Location:70200
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    pfam01534
    Location:225554
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    57019941..57041779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    53450322..53474674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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