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Mapk10 mitogen activated protein kinase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25272, updated on 2-Nov-2024

Summary

Official Symbol
Mapk10provided by RGD
Official Full Name
mitogen activated protein kinase 10provided by RGD
Primary source
RGD:3663
See related
EnsemblRapid:ENSRNOG00000002079 AllianceGenome:RGD:3663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Jnk3; SAPb; SAPKC; Serk2
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression
Biased expression in Brain (RPKM 116.3), Testes (RPKM 7.1) and 1 other tissue See more
Orthologs
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Genomic context

See Mapk10 in Genome Data Viewer
Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6802247..7094103)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (6497662..6790109)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (8079955..8371508)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481700 Neighboring gene uncharacterized LOC108352699 Neighboring gene small ribosomal subunit protein eS25-like Neighboring gene uncharacterized LOC120096564 Neighboring gene cytochrome c oxidase assembly protein COX20, mitochondrial-like Neighboring gene peptidyl-prolyl cis-trans isomerase FKBP2-like Neighboring gene uncharacterized LOC134481822 Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC134481821

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in JUN phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular hyperosmotic response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in locomotor rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor transport to postsynaptic membrane EXP
Inferred from Experiment
more info
PubMed 
involved_in neurotransmitter receptor transport to postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor transport to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport in synapse EXP
Inferred from Experiment
more info
PubMed 
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 10
Names
MAP kinase 10
MAPK 10
SAPK-beta
Stress activated protein kinase beta
c-Jun N-terminal kinase 3
p54-beta
stress-activated protein kinase JNK3
NP_001257485.1
NP_001305119.1
NP_036938.2
XP_017454572.1
XP_017454573.1
XP_063128936.1
XP_063128937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270556.1NP_001257485.1  mitogen-activated protein kinase 10 isoform 1

    See identical proteins and their annotated locations for NP_001257485.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    FQ083521, FQ084081, FQ211777
    UniProtKB/Swiss-Prot
    B0VXR6, D3ZQ33, P49187
    UniProtKB/TrEMBL
    A6K5V7
    Related
    ENSRNOP00000075846.3, ENSRNOT00000092395.3
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001318190.1NP_001305119.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    FQ083521, FQ084081, FQ211777
    UniProtKB/Swiss-Prot
    B0VXR6, D3ZQ33, P49187
    Conserved Domains (2) summary
    smart00220
    Location:64359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. NM_012806.2NP_036938.2  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_036938.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2, also known as SAPK beta) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    FQ083521, FQ084081, FQ211777, L27128
    UniProtKB/TrEMBL
    A0A8L2RB61
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    6802247..7094103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272867.1XP_063128937.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A0U1RVI2
    Related
    ENSRNOP00000060904.5, ENSRNOT00000065965.6
  2. XM_017599084.3XP_017454573.1  mitogen-activated protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RRS7
    Related
    ENSRNOP00000075755.3, ENSRNOT00000092719.3
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. XM_017599083.3XP_017454572.1  mitogen-activated protein kinase 10 isoform X1

    UniProtKB/TrEMBL
    A0A8L2RB61
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. XM_063272866.1XP_063128936.1  mitogen-activated protein kinase 10 isoform X2

    Related
    ENSRNOP00000109602.1, ENSRNOT00000169826.1