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Pdgfa platelet derived growth factor subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25266, updated on 10-Oct-2019

Summary

Official Symbol
Pdgfaprovided by RGD
Official Full Name
platelet derived growth factor subunit Aprovided by RGD
Primary source
RGD:3282
See related
Ensembl:ENSRNOG00000001312
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PDGFACP
Summary
alpha chain of platelet derived growth factor; acts as a homodimer or heterodimer with PDGF beta to activate PDGF receptors [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 73.3), Heart (RPKM 72.3) and 9 other tissues See more
Orthologs

Genomic context

See Pdgfa in Genome Data Viewer
Location:
12q11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17734141..17756186)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (19727672..19749009)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC103691050 Neighboring gene LRRGT00167 Neighboring gene 40S ribosomal protein S27-like Neighboring gene similar to Forkhead box protein L1 (Forkhead-related protein FKHL11) (Forkhead-related transcription factor 7) (FREAC-7)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
collagen binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
collagen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet-derived growth factor binding IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet-derived growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
animal organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
PubMed 
cell projection assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
cell projection assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
digestive tract development ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic lung development ISO
Inferred from Sequence Orthology
more info
PubMed 
hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
inner ear development IEP
Inferred from Expression Pattern
more info
PubMed 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
PubMed 
lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of phosphatidylinositol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT regulation of glomerular mesangial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
skin development ISO
Inferred from Sequence Orthology
more info
PubMed 
skin development ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular_component ND
No biological Data available
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
PubMed 
microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
platelet-derived growth factor subunit A
Names
PDGF subunit A
PDGF-1
Platelet-derived growth factor A chain
platelet derived growth factor, alpha
platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012801.1NP_036933.1  platelet-derived growth factor subunit A precursor

    See identical proteins and their annotated locations for NP_036933.1

    Status: PROVISIONAL

    Source sequence(s)
    L06238
    UniProtKB/Swiss-Prot
    P28576
    Related
    ENSRNOP00000040116.4, ENSRNOT00000042117.6
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    17734141..17756186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248918.2XP_006248980.1  platelet-derived growth factor subunit A isoform X1

    See identical proteins and their annotated locations for XP_006248980.1

    UniProtKB/TrEMBL
    Q6P7C3
    Related
    ENSRNOP00000074787.1, ENSRNOT00000091476.1
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    17398134..17419591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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