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Pdgfa platelet derived growth factor subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25266, updated on 25-Jan-2022

Summary

Official Symbol
Pdgfaprovided by RGD
Official Full Name
platelet derived growth factor subunit Aprovided by RGD
Primary source
RGD:3282
See related
Ensembl:ENSRNOG00000001312 AllianceGenome:RGD:3282
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PDGFACP
Summary
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including male gonad development; response to estradiol; and response to retinoic acid. Predicted to be located in cell surface and microvillus. Predicted to be active in extracellular space. Biomarker of chronic ulcer of skin; oligohydramnios; pancreatitis; pulmonary hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 73.3), Heart (RPKM 72.3) and 9 other tissues See more
Orthologs
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Genomic context

See Pdgfa in Genome Data Viewer
Location:
12q11
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15645549..15667056)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17734141..17756186)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC103691050 Neighboring gene LRRGT00167 Neighboring gene 40S ribosomal protein S27-like Neighboring gene forkhead box L3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cell projection assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within digestive tract development ISO
Inferred from Sequence Orthology
more info
 
involved_in digestive tract development ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in hair follicle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inner ear development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of glomerular mesangial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
 
involved_in skin development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of platelet-derived growth factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet-derived growth factor subunit A
Names
PDGF subunit A
PDGF-1
Platelet-derived growth factor A chain
platelet derived growth factor, alpha
platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012801.2NP_036933.2  platelet-derived growth factor subunit A precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000225
    Related
    ENSRNOP00000040116.4, ENSRNOT00000042117.7
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    15645549..15667056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089107.1XP_038945035.1  platelet-derived growth factor subunit A isoform X1

    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  2. XM_039089105.1XP_038945033.1  platelet-derived growth factor subunit A isoform X2

    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  3. XM_039089104.1XP_038945032.1  platelet-derived growth factor subunit A isoform X1

    Related
    ENSRNOP00000074787.1, ENSRNOT00000091476.2
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  4. XM_039089106.1XP_038945034.1  platelet-derived growth factor subunit A isoform X2

    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
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