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Gamt guanidinoacetate N-methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25257, updated on 21-Jul-2018

Summary

Official Symbol
Gamtprovided by RGD
Official Full Name
guanidinoacetate N-methyltransferaseprovided by RGD
Primary source
RGD:2659
See related
Ensembl:ENSRNOG00000024577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GMT
Summary
catalyzes the last step of creatine biosynthesis [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 1351.4), Kidney (RPKM 300.0) and 6 other tissues See more
Orthologs

Genomic context

See Gamt in Genome Data Viewer
Location:
7q11
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12314848..12317998)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (12484097..12487698)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 2310011J03 Neighboring gene APC2, WNT signaling pathway regulator Neighboring gene ribosomal protein S15 Neighboring gene DAZ associated protein 1 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S7 Neighboring gene transfer RNA asparagine (anticodon GUU) Neighboring gene transfer RNA phenylalanine (anticodon GAA)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanidinoacetate N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanidinoacetate N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
guanidinoacetate N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
guanidinoacetate N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
guanidinoacetate N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
guanidinoacetate N-methyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
S-adenosylhomocysteine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylhomocysteine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
S-adenosylmethionine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S-adenosylmethionine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
creatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
creatine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
creatine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
creatine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
creatine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
embryonic liver development IEP
Inferred from Expression Pattern
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
guanidinoacetate N-methyltransferase
Names
guanidinoacetate methyltransferase
NP_036925.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012793.2NP_036925.2  guanidinoacetate N-methyltransferase

    See identical proteins and their annotated locations for NP_036925.2

    Status: VALIDATED

    Source sequence(s)
    BF524958, FM040945, FQ225896
    UniProtKB/TrEMBL
    G3V960
    Related
    ENSRNOP00000036927.2, ENSRNOT00000028969.4
    Conserved Domains (1) summary
    cd02440
    Location:63166
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    12314848..12317998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    7625330..7628480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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