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Grk2 G protein-coupled receptor kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25238, updated on 14-Aug-2021

Summary

Official Symbol
Grk2provided by RGD
Official Full Name
G protein-coupled receptor kinase 2provided by RGD
Primary source
RGD:2062
See related
Ensembl:ENSRNOG00000018985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BARK1; GRK-2; Adrbk1
Summary
catalzyes phosphorylation of the beta-adrenergic receptor; may mediate desensitizaton of synaptic receptors; may regulate bone formation [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 477.7), Spleen (RPKM 331.9) and 9 other tissues See more
Orthologs
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Genomic context

See Grk2 in Genome Data Viewer
Location:
1q43
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201581480..201601580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219536220..219544329, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13D Neighboring gene slingshot protein phosphatase 3 Neighboring gene lysine demethylase 2A Neighboring gene small nucleolar RNA SNORA32 Neighboring gene ras homolog family member D

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Edg-2 lysophosphatidic acid receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables Edg-2 lysophosphatidic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables beta-adrenergic receptor kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-adrenergic receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables delta-type opioid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kappa-type opioid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to catecholamine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to chemokine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to phorbol 13-acetate 12-myristate IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to rapamycin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in desensitization of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in follicle-stimulating hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of relaxation of smooth muscle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of relaxation of smooth muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of relaxation of smooth muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of striated muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of the force of heart contraction by chemical signal IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of the force of heart contraction by chemical signal ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catecholamine secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of the force of heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in response to caloric restriction IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to leptin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to morphine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to muscle activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tachykinin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in tachykinin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in viral genome replication ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beta-adrenergic receptor kinase 1
Names
adrenergic receptor kinase, beta 1
adrenergic, beta, receptor kinase 1
beta-ARK-1
beta-adrenergic receptor kinase 1 beta ARK1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012776.2NP_036908.2  beta-adrenergic receptor kinase 1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000045
    Related
    ENSRNOP00000025847.5, ENSRNOT00000025847.7
    Conserved Domains (3) summary
    cd08747
    Location:30186
    RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
    cd01240
    Location:553670
    PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
    cd14223
    Location:190510
    STKc_GRK2; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    201581480..201601580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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