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Acvrl1 activin A receptor like type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25237, updated on 23-Jun-2022

Summary

Official Symbol
Acvrl1provided by RGD
Official Full Name
activin A receptor like type 1provided by RGD
Primary source
RGD:2029
See related
Ensembl:ENSRNOG00000028713 AllianceGenome:RGD:2029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
R3; R-3; Alk1; SETHKIR
Summary
Predicted to enable several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in response to hypoxia. Located in cell surface; dendrite; and neuronal cell body. Biomarker of pulmonary hypertension and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (activin A receptor like type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 529.2), Heart (RPKM 83.6) and 6 other tissues See more
Orthologs
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Genomic context

See Acvrl1 in Genome Data Viewer
Location:
7q36
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132239200..132256592)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142769942..142787336)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093740 Neighboring gene ankyrin repeat domain 33 Neighboring gene activin A receptor type 1B Neighboring gene uncharacterized LOC103692984 Neighboring gene trafficking regulator and scaffold protein tamalin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC91691

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables BMP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transforming growth factor beta receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in artery development ISO
Inferred from Sequence Orthology
more info
 
involved_in blood circulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in endocardial cushion to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in venous blood vessel development ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BMP receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase receptor R3
Names
Activin receptor like kinase 1
SKR3
TGF-B superfamily receptor type I
TSR-I
activin A receptor type II-like 1
activin A receptor type IL
NP_071886.1
XP_006242365.1
XP_038934369.1
XP_038934371.1
XP_038934372.1
XP_038934373.1
XP_038934374.1
XP_038934375.1
XP_038934376.1
XP_038934377.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022441.2NP_071886.1  serine/threonine-protein kinase receptor R3 precursor

    See identical proteins and their annotated locations for NP_071886.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083173
    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    132239200..132256592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242303.3XP_006242365.1  serine/threonine-protein kinase receptor R3 isoform X1

    See identical proteins and their annotated locations for XP_006242365.1

    UniProtKB/Swiss-Prot
    P80203
    Related
    ENSRNOP00000008673.3, ENSRNOT00000008673.5
    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  2. XM_039078447.1XP_038934375.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  3. XM_039078441.1XP_038934369.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  4. XM_039078443.1XP_038934371.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  5. XM_039078446.1XP_038934374.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  6. XM_039078445.1XP_038934373.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  7. XM_039078444.1XP_038934372.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  8. XM_039078448.1XP_038934376.1  serine/threonine-protein kinase receptor R3 isoform X1

    Conserved Domains (2) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  9. XM_039078449.1XP_038934377.1  serine/threonine-protein kinase receptor R3 isoform X2

    Conserved Domains (2) summary
    cd14142
    Location:24321
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam08515
    Location:128
    TGF_beta_GS; Transforming growth factor beta type I GS-motif