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Acvrl1 activin A receptor like type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25237, updated on 12-Aug-2018
Official Symbol
Acvrl1provided by RGD
Official Full Name
activin A receptor like type 1provided by RGD
Primary source
RGD:2029
See related
Ensembl:ENSRNOG00000028713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
R3; R-3; Alk1; SETHKIR
Summary
may play a role in TGF-beta mediated transmembrane signaling in blood vessels [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 529.2), Heart (RPKM 83.6) and 6 other tissues See more
Orthologs
See Acvrl1 in Genome Data Viewer
Location:
7q36
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142769942..142787336)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (140571236..140588083)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene fidgetin-like 2 Neighboring gene ankyrin repeat domain 33 Neighboring gene activin A receptor type 1B Neighboring gene uncharacterized LOC103692983 Neighboring gene uncharacterized LOC103692984 Neighboring gene general receptor for phosphoinositides 1 associated scaffold protein

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...

Markers

Homology

Clone Names

  • MGC91691

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
BMP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP receptor activity ISO
Inferred from Sequence Orthology
more info
 
BMP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
activin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin binding IEA
Inferred from Electronic Annotation
more info
 
activin binding ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 
activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor activity, type I IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
artery development ISO
Inferred from Sequence Orthology
more info
 
blood circulation ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT endocardial cushion to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
endothelial tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
lymphangiogenesis IEA
Inferred from Electronic Annotation
more info
 
lymphangiogenesis ISO
Inferred from Sequence Orthology
more info
 
lymphatic endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphatic endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
retina vasculature development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
venous blood vessel development IEA
Inferred from Electronic Annotation
more info
 
venous blood vessel development ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of epidermal cells IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
serine/threonine-protein kinase receptor R3
Names
Activin receptor like kinase 1
SKR3
TGF-B superfamily receptor type I
TSR-I
activin A receptor type II-like 1
activin A receptor type IL
NP_071886.1
XP_006242365.1
XP_006242366.1
XP_006242367.1
XP_008763895.1
XP_017450156.1
XP_017450157.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022441.2NP_071886.1  serine/threonine-protein kinase receptor R3 precursor

    See identical proteins and their annotated locations for NP_071886.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083173
    UniProtKB/Swiss-Prot
    P80203
    Related
    ENSRNOP00000008673.3, ENSRNOT00000008673.4
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    142769942..142787336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242303.3XP_006242365.1  serine/threonine-protein kinase receptor R3 isoform X1

    See identical proteins and their annotated locations for XP_006242365.1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  2. XM_017594668.1XP_017450157.1  serine/threonine-protein kinase receptor R3 isoform X1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  3. XM_017594667.1XP_017450156.1  serine/threonine-protein kinase receptor R3 isoform X1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  4. XM_008765673.2XP_008763895.1  serine/threonine-protein kinase receptor R3 isoform X1

    See identical proteins and their annotated locations for XP_008763895.1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  5. XM_006242305.3XP_006242367.1  serine/threonine-protein kinase receptor R3 isoform X1

    See identical proteins and their annotated locations for XP_006242367.1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  6. XM_006242304.3XP_006242366.1  serine/threonine-protein kinase receptor R3 isoform X1

    See identical proteins and their annotated locations for XP_006242366.1

    UniProtKB/Swiss-Prot
    P80203
    Conserved Domains (4) summary
    cd14142
    Location:197494
    STKc_ACVR1_ALK1; Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1
    pfam07714
    Location:203490
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:174201
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl10471
    Location:3599
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    128712554..128723633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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