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Gpc3 glypican 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25236, updated on 30-Sep-2021

Summary

Official Symbol
Gpc3provided by RGD
Official Full Name
glypican 3provided by RGD
Primary source
RGD:2725
See related
EnsemblRapid:ENSRNOG00000060179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OCI-5
Summary
heparan sulfate cell surface proteogycan, may be involved in development of mesodermal tissues, may modulate Igf2 function [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 1010.0), Kidney (RPKM 338.9) and 5 other tissues See more
Orthologs
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Genomic context

See Gpc3 in Genome Data Viewer
Location:
Xq36
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (131868983..132236837, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (139579268..139947093, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L7 Neighboring gene high mobility group protein B4-like Neighboring gene uncharacterized LOC120099376 Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA 92a-2 Neighboring gene microRNA 363

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93606

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables peptidyl-dipeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-dipeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-dipeptidase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anterior/posterior axis specification ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within body morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bone mineralization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration involved in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell proliferation involved in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell proliferation involved in kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell proliferation involved in metanephros development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell proliferation involved in metanephros development ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in coronary vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal cell proliferation involved in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell proliferation involved in ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesonephric duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mesonephric duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mesonephric duct morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in anchored component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glypican-3
Names
defective in Simpson-Golabi-Behmel overgrowth syndrome
intestinal protein OCI-5
proteoglycan GPC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012774.2NP_036906.2  glypican-3 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000467
    Conserved Domains (1) summary
    pfam01153
    Location:14576
    Glypican

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    131868983..132236837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099498.1XP_038955426.1  glypican-3 isoform X1

    Related
    ENSRNOP00000075712.2, ENSRNOT00000090442.2
    Conserved Domains (1) summary
    pfam01153
    Location:14576
    Glypican
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