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Onecut1 one cut homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25231, updated on 17-Oct-2021

Summary

Official Symbol
Onecut1provided by RGD
Official Full Name
one cut homeobox 1provided by RGD
Primary source
RGD:2811
See related
EnsemblRapid:ENSRNOG00000008095
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hnf6
Summary
transcription factor; acts as a transcriptional activator of liver promoter sequence [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 154.0) See more
Orthologs
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Genomic context

See Onecut1 in Genome Data Viewer
Location:
8q24
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (75599432..75633598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (81765779..81799894)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC102549203 Neighboring gene family with sequence similarity 214, member A Neighboring gene cAMP-regulated phosphoprotein 19

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in endoderm development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spleen development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hepatocyte nuclear factor 6
Names
HNF-6
one cut domain, family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022671.3NP_073162.2  hepatocyte nuclear factor 6

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000199
    Related
    ENSRNOP00000038480.3, ENSRNOT00000032280.5
    Conserved Domains (2) summary
    smart00389
    Location:385440
    HOX; Homeodomain
    pfam02376
    Location:290362
    CUT; CUT domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    75599432..75633598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243404.4XP_006243466.1  hepatocyte nuclear factor 6 isoform X1

    See identical proteins and their annotated locations for XP_006243466.1

    Related
    ENSRNOP00000096278.1, ENSRNOT00000101262.1
    Conserved Domains (2) summary
    smart00389
    Location:411466
    HOX; Homeodomain
    pfam02376
    Location:290362
    CUT; CUT domain
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