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Gdi1 GDP dissociation inhibitor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25183, updated on 8-Dec-2022

Summary

Official Symbol
Gdi1provided by RGD
Official Full Name
GDP dissociation inhibitor 1provided by RGD
Primary source
RGD:2676
See related
Ensembl:ENSRNOG00000056870 AllianceGenome:RGD:2676
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Involved in negative regulation of axonogenesis; positive regulation of axon extension; and response to calcium ion. Located in axon; myelin sheath; and neuronal cell body. Part of protein-containing complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 830.0), Adrenal (RPKM 688.0) and 9 other tissues See more
Orthologs
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Genomic context

See Gdi1 in Genome Data Viewer
Location:
Xq37
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (152087611..152094274)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156400734..156407396, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene ATPase H+ transporting accessory protein 1 Neighboring gene family with sequence similarity 50, member A Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene uncharacterized LOC102548378

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC108721

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables Rab GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Rab GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Rab GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rab GDP dissociation inhibitor alpha
Names
GDI-1
guanosine diphosphate dissociation inhibitor 1
rab GDI alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017088.2NP_058784.2  rab GDP dissociation inhibitor alpha

    See identical proteins and their annotated locations for NP_058784.2

    Status: PROVISIONAL

    Source sequence(s)
    BC099763
    UniProtKB/Swiss-Prot
    P50398, Q9R274
    Related
    ENSRNOP00000070171.1, ENSRNOT00000089814.2
    Conserved Domains (1) summary
    pfam00996
    Location:1436
    GDI; GDP dissociation inhibitor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    152087611..152094274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)