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Gata2 GATA binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25159, updated on 12-Aug-2018

Summary

Official Symbol
Gata2provided by RGD
Official Full Name
GATA binding protein 2provided by RGD
Primary source
RGD:2664
See related
Ensembl:ENSRNOG00000012347
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
mediates phagocytosis function of alveolar macrophages [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 128.3), Uterus (RPKM 75.4) and 7 other tissues See more
Orthologs

Genomic context

See Gata2 in Genome Data Viewer
Location:
4q34
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120129028..120142490)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (185369926..185383944)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692180 Neighboring gene uncharacterized LOC102554068 Neighboring gene uncharacterized LOC108350728 Neighboring gene DnaJ heat shock protein family (Hsp40) member B8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
C2H2 zinc finger domain binding IEA
Inferred from Electronic Annotation
more info
 
C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GABAergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
GABAergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
anatomical structure formation involved in morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation in hindbrain IEA
Inferred from Electronic Annotation
more info
 
cell differentiation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
cell fate determination IEA
Inferred from Electronic Annotation
more info
 
cell fate determination ISO
Inferred from Sequence Orthology
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell maturation ISO
Inferred from Sequence Orthology
more info
 
central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
cochlea development IEP
Inferred from Expression Pattern
more info
PubMed 
commitment of neuronal cell to specific neuron type in forebrain IEA
Inferred from Electronic Annotation
more info
 
commitment of neuronal cell to specific neuron type in forebrain ISO
Inferred from Sequence Orthology
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
eosinophil fate commitment IEA
Inferred from Electronic Annotation
more info
 
eosinophil fate commitment ISO
Inferred from Sequence Orthology
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of forebrain neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
regulation of primitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
semicircular canal development IEA
Inferred from Electronic Annotation
more info
 
semicircular canal development ISO
Inferred from Sequence Orthology
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
urogenital system development IEA
Inferred from Electronic Annotation
more info
 
urogenital system development ISO
Inferred from Sequence Orthology
more info
 
ventral spinal cord interneuron differentiation IEA
Inferred from Electronic Annotation
more info
 
ventral spinal cord interneuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endothelial transcription factor GATA-2
Names
GATA-bindning protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033442.1NP_254277.1  endothelial transcription factor GATA-2

    See identical proteins and their annotated locations for NP_254277.1

    Status: PROVISIONAL

    Source sequence(s)
    AY032734
    UniProtKB/Swiss-Prot
    Q924Y4
    UniProtKB/TrEMBL
    B2DBE1
    Related
    ENSRNOP00000017240.1, ENSRNOT00000017240.2
    Conserved Domains (2) summary
    smart00401
    Location:344393
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:349398
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    120129028..120142490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592480.1XP_017447969.1  endothelial transcription factor GATA-2 isoform X1

    UniProtKB/Swiss-Prot
    Q924Y4
    UniProtKB/TrEMBL
    B2DBE1
  2. XM_017592479.1XP_017447968.1  endothelial transcription factor GATA-2 isoform X1

    UniProtKB/Swiss-Prot
    Q924Y4
    UniProtKB/TrEMBL
    B2DBE1

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    109615354..109624129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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