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Gata2 GATA binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25159, updated on 12-Jan-2022

Summary

Official Symbol
Gata2provided by RGD
Official Full Name
GATA binding protein 2provided by RGD
Primary source
RGD:2664
See related
Ensembl:ENSRNOG00000012347
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including cochlea development; neuron migration; and regulation of vesicle-mediated transport. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; immunodeficiency 21; mental depression; myelodysplastic syndrome; and myeloid leukemia. Orthologous to human GATA2 (GATA binding protein 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Lung (RPKM 128.3), Uterus (RPKM 75.4) and 7 other tissues See more
Orthologs
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Genomic context

See Gata2 in Genome Data Viewer
Location:
4q34
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120654205..120667763)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120129028..120142490)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102332 Neighboring gene uncharacterized LOC103692180 Neighboring gene uncharacterized LOC102554068 Neighboring gene uncharacterized LOC120102333 Neighboring gene DnaJ heat shock protein family (Hsp40) member B8 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene t-complex protein 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within GABAergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell fate determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil fate commitment ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of primitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within semicircular canal development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within urogenital system development ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endothelial transcription factor GATA-2
Names
GATA-bindning protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033442.1NP_254277.1  endothelial transcription factor GATA-2

    See identical proteins and their annotated locations for NP_254277.1

    Status: PROVISIONAL

    Source sequence(s)
    AY032734
    UniProtKB/Swiss-Prot
    Q924Y4
    UniProtKB/TrEMBL
    B2DBE1
    Related
    ENSRNOP00000017240.1, ENSRNOT00000017240.3
    Conserved Domains (1) summary
    cd00202
    Location:349398
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    120654205..120667763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107091.1XP_038963019.1  endothelial transcription factor GATA-2 isoform X1

    Conserved Domains (1) summary
    cd00202
    Location:349398
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
  2. XM_017592480.2XP_017447969.1  endothelial transcription factor GATA-2 isoform X1

    UniProtKB/Swiss-Prot
    Q924Y4
    UniProtKB/TrEMBL
    B2DBE1
    Conserved Domains (1) summary
    cd00202
    Location:349398
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
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