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Igf2r insulin-like growth factor 2 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25151, updated on 18-Apr-2019

Summary

Official Symbol
Igf2rprovided by RGD
Official Full Name
insulin-like growth factor 2 receptorprovided by RGD
Primary source
RGD:2871
See related
Ensembl:ENSRNOG00000014997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igfr2; IGF-IIR
Summary
mediates internalization of insulin-like growth factor II; plays a role in lysosomal enzyme transport [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 538.7), Heart (RPKM 422.5) and 9 other tissues See more
Orthologs

Genomic context

See Igf2r in Genome Data Viewer
Location:
1q11
Exon count:
48
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48176095..48264482)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (51488767..51577141, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene PARN like, ribonuclease domain containing 1 Neighboring gene MAS1 proto-oncogene like, G protein-coupled receptor Neighboring gene MAS1 proto-oncogene, G protein-coupled receptor Neighboring gene solute carrier family 22 member 1 Neighboring gene solute carrier family 22 member 2 Neighboring gene protein LSM12 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
insulin-like growth factor II binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
insulin-like growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannose binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
liver development IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IEP
Inferred from Expression Pattern
more info
PubMed 
protein transport TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
clathrin coat IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nuclear envelope lumen IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
PubMed 
trans-Golgi network transport vesicle IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cation-independent mannose-6-phosphate receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012756.2NP_036888.2  cation-independent mannose-6-phosphate receptor precursor

    Status: VALIDATED

    Source sequence(s)
    AC114389, AC129234
    UniProtKB/TrEMBL
    G3V824
    Related
    ENSRNOP00000021840.3, ENSRNOT00000021840.4
    Conserved Domains (3) summary
    smart00059
    Location:18881933
    FN2; Fibronectin type 2 domain
    pfam00878
    Location:10221169
    CIMR; Cation-independent mannose-6-phosphate receptor repeat
    pfam02157
    Location:12021354
    Man-6-P_recep; Mannose-6-phosphate receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    48176095..48264482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    43778518..43867238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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