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Igf2r insulin-like growth factor 2 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25151, updated on 6-May-2021

Summary

Official Symbol
Igf2rprovided by RGD
Official Full Name
insulin-like growth factor 2 receptorprovided by RGD
Primary source
RGD:2871
See related
Ensembl:ENSRNOG00000014997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Igfr2; IGF-IIR
Summary
mediates internalization of insulin-like growth factor II; plays a role in lysosomal enzyme transport [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 538.7), Heart (RPKM 422.5) and 9 other tissues See more
Orthologs
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Genomic context

See Igf2r in Genome Data Viewer
Location:
1q11
Exon count:
48
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (47979109..48067501)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48176095..48264482)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene MAS1 proto-oncogene, G protein-coupled receptor Neighboring gene uncharacterized LOC120099123 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene solute carrier family 22 member 1 Neighboring gene solute carrier family 22 member 2 Neighboring gene protein LSM12 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor II binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables mannose binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cation-independent mannose-6-phosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012756.2NP_036888.2  cation-independent mannose-6-phosphate receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000017
    UniProtKB/TrEMBL
    G3V824
    Related
    ENSRNOP00000021840.3, ENSRNOT00000021840.4
    Conserved Domains (3) summary
    smart00059
    Location:18881933
    FN2; Fibronectin type 2 domain
    pfam00878
    Location:10221169
    CIMR; Cation-independent mannose-6-phosphate receptor repeat
    pfam02157
    Location:12021354
    Man-6-P_recep; Mannose-6-phosphate receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    47979109..48067501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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