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Fyn FYN proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25150, updated on 8-Dec-2018

Summary

Official Symbol
Fynprovided by RGD
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by RGD
Primary source
RGD:2641
See related
Ensembl:ENSRNOG00000000596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may mediate tyrosine phosphorylation of Cbl protein in cerebellum in response to ethanol administration [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 146.3), Brain (RPKM 137.2) and 9 other tissues See more
Orthologs

Genomic context

See Fyn in Genome Data Viewer
Location:
20q12
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44436354..44630316)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (46160734..46353456)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene tubulin, epsilon 1 Neighboring gene uncharacterized LOC108349081 Neighboring gene cellular communication network factor 6 Neighboring gene claudin-7 pseudogene Neighboring gene uncharacterized LOC108349083 Neighboring gene uncharacterized LOC108349084 Neighboring gene uncharacterized LOC102551236 Neighboring gene Traf3 interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CD4 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
CD8 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
T cell receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
type 5 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to L-glutamate IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to glycine IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
detection of mechanical stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
forebrain development ISO
Inferred from Sequence Orthology
more info
 
heart process IEA
Inferred from Electronic Annotation
more info
 
heart process ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oxidative stress-induced cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to singlet oxygen IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
actin filament IEA
Inferred from Electronic Annotation
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glial cell projection IEA
Inferred from Electronic Annotation
more info
 
glial cell projection ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Fyn
Names
FYN oncogene related to SRC, FGR, YES
p59-Fyn
proto-oncogene c-Fyn
proto-oncogene tyrosine-protein kinase Fyn
NP_036887.1
XP_006256584.1
XP_017457038.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012755.1NP_036887.1  tyrosine-protein kinase Fyn

    See identical proteins and their annotated locations for NP_036887.1

    Status: PROVISIONAL

    Source sequence(s)
    U35365
    UniProtKB/Swiss-Prot
    Q62844
    Related
    ENSRNOP00000000733.1, ENSRNOT00000000733.4
    Conserved Domains (3) summary
    cd10418
    Location:145245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    44436354..44630316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256522.1XP_006256584.1  tyrosine-protein kinase Fyn isoform X2

    Conserved Domains (4) summary
    cd10418
    Location:183283
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:123178
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:299572
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
    pfam07714
    Location:309558
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_017601549.1XP_017457038.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A096MKC1
    Related
    ENSRNOP00000068458.1, ENSRNOT00000076859.2

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    43482980..43675123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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