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Slc2a4 solute carrier family 2 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25139, updated on 6-Sep-2021

Summary

Official Symbol
Slc2a4provided by RGD
Official Full Name
solute carrier family 2 member 4provided by RGD
Primary source
RGD:2711
See related
Ensembl:ENSRNOG00000017226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Glut4
Summary
transports glucose; may play a role in insulin response [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 955.0), Heart (RPKM 746.4) and 4 other tissues See more
Orthologs
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Genomic context

See Slc2a4 in Genome Data Viewer
Location:
10q24
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54666015..54671581, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56552921..56558562, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box binding protein 2 Neighboring gene cofilin-1-like Neighboring gene claudin 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93607

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within amylopectin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose import in response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucose import in response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import in response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning or memory IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle budding from presynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within_negative_effect short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in insulin-responsive compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
GLUT-4
Glucose transporter 4, insuline-responsive
glucose transporter type 4, insulin-responsive
insulin responsive glucose transporter
solute carrier family 2 (facilitated glucose transporter), member 4
solute carrier family 2 , member 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012751.1NP_036883.1  solute carrier family 2, facilitated glucose transporter member 4

    See identical proteins and their annotated locations for NP_036883.1

    Status: PROVISIONAL

    Source sequence(s)
    D28561
    UniProtKB/Swiss-Prot
    P19357
    Related
    ENSRNOP00000023256.3, ENSRNOT00000023256.5
    Conserved Domains (2) summary
    cd06174
    Location:78447
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    54666015..54671581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246596.4XP_006246658.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

    See identical proteins and their annotated locations for XP_006246658.1

    UniProtKB/Swiss-Prot
    P19357
    Conserved Domains (2) summary
    cd06174
    Location:78447
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:27483
    Sugar_tr; Sugar (and other) transporter
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