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Gfra2 GDNF family receptor alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25136, updated on 2-Oct-2018

Summary

Official Symbol
Gfra2provided by RGD
Official Full Name
GDNF family receptor alpha 2provided by RGD
Primary source
RGD:61809
See related
Ensembl:ENSRNOG00000014010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Retl2
Summary
stimulates c-Ret tyrosine phosphorylation by mediating a crosslink with GDNF of c-Ret [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 77.1), Lung (RPKM 66.4) and 7 other tissues See more
Orthologs

Genomic context

See Gfra2 in Genome Data Viewer
Location:
15p11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52557004..52648984)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (56280942..56372308)

Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene exportin 7 Neighboring gene docking protein 2 Neighboring gene phytanoyl-CoA hydroxylase-interacting protein Neighboring gene similar to PRAME family member 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glial cell-derived neurotrophic factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glial cell-derived neurotrophic factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GDNF family receptor alpha-2
Names
glial cell line derived neurotrophic factor family receptor alpha 2
tyrosine kinase receptor ligand 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012750.1NP_036882.1  GDNF family receptor alpha-2 precursor

    See identical proteins and their annotated locations for NP_036882.1

    Status: PROVISIONAL

    Source sequence(s)
    U97143
    UniProtKB/TrEMBL
    O35977
    Related
    ENSRNOP00000019222.2, ENSRNOT00000019222.3
    Conserved Domains (2) summary
    smart00907
    Location:40113
    GDNF; GDNF/GAS1 domain
    pfam02351
    Location:251347
    GDNF; GDNF/GAS1 domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

    Range
    52557004..52648984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599582.1XP_017455071.1  GDNF family receptor alpha-2 isoform X2

  2. XM_017599583.1XP_017455072.1  GDNF family receptor alpha-2 isoform X3

  3. XM_006252238.3XP_006252300.1  GDNF family receptor alpha-2 isoform X1

    Conserved Domains (2) summary
    smart00907
    Location:82155
    GDNF; GDNF/GAS1 domain
    pfam02351
    Location:293389
    GDNF; GDNF/GAS1 domain

Alternate Rn_Celera

Genomic

  1. AC_000083.1 Alternate Rn_Celera

    Range
    45618968..45709881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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