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Stat5b signal transducer and activator of transcription 5B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25126, updated on 12-Aug-2018

Summary

Official Symbol
Stat5bprovided by RGD
Official Full Name
signal transducer and activator of transcription 5Bprovided by RGD
Primary source
RGD:3774
See related
Ensembl:ENSRNOG00000019075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
member of the STAT family of transcription factors; may mediate biological actions of several interleukins and growth hormones; may be associated with mammary gland development and lactation [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Expression
Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues See more
Orthologs

Genomic context

See Stat5b in Genome Data Viewer
Location:
10q31
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88686207..88712313, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (88480377..88506888, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5A Neighboring gene signal transducer and activator of transcription 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
    EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystem
    Endochondral Ossification
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Growth hormone receptor signaling, organism-specific biosystem (from REACTOME)
    Growth hormone receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystem
    IL-5 Signaling Pathway
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystem
    IL-6 Signaling Pathway
  • IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-9 Signaling Pathway, organism-specific biosystem
    IL-9 Signaling Pathway
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-7 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • JAK-STAT signaling, organism-specific biosystem (from KEGG)
    JAK-STAT signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • JAK-STAT signaling, conserved biosystem (from KEGG)
    JAK-STAT signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
    Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Non-small cell lung cancer, conserved biosystem (from KEGG)
    Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
    Prolactin receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
    Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
    Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
 
2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Peyer's patch development IEA
Inferred from Electronic Annotation
more info
 
Peyer's patch development ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
acute-phase response IDA
Inferred from Direct Assay
more info
PubMed 
allantoin metabolic process IEA
Inferred from Electronic Annotation
more info
 
allantoin metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
citrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
creatine metabolic process IEA
Inferred from Electronic Annotation
more info
 
creatine metabolic process ISO
Inferred from Sequence Orthology
more info
 
creatinine metabolic process IEA
Inferred from Electronic Annotation
more info
 
creatinine metabolic process ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
development of secondary female sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
development of secondary female sexual characteristics ISO
Inferred from Sequence Orthology
more info
 
development of secondary male sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
development of secondary male sexual characteristics ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
female pregnancy ISO
Inferred from Sequence Orthology
more info
 
isoleucine metabolic process IEA
Inferred from Electronic Annotation
more info
 
isoleucine metabolic process ISO
Inferred from Sequence Orthology
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
lactation ISO
Inferred from Sequence Orthology
more info
 
lipid storage IEA
Inferred from Electronic Annotation
more info
 
lipid storage ISO
Inferred from Sequence Orthology
more info
 
liver development IDA
Inferred from Direct Assay
more info
PubMed 
luteinization IDA
Inferred from Direct Assay
more info
PubMed 
luteinization IEA
Inferred from Electronic Annotation
more info
 
luteinization ISO
Inferred from Sequence Orthology
more info
 
mast cell migration IEA
Inferred from Electronic Annotation
more info
 
mast cell migration ISO
Inferred from Sequence Orthology
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
oxaloacetate metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular component movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gamma-delta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-2 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-2 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 
progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-15 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-15 ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-2 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-2 ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
response to interleukin-4 ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
sex differentiation ISO
Inferred from Sequence Orthology
more info
 
succinate metabolic process IEA
Inferred from Electronic Annotation
more info
 
succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
taurine metabolic process IEA
Inferred from Electronic Annotation
more info
 
taurine metabolic process ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
valine metabolic process IEA
Inferred from Electronic Annotation
more info
 
valine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 5B
Names
Signal transducer and activator of transcription 5a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022380.1NP_071775.1  signal transducer and activator of transcription 5B

    See identical proteins and their annotated locations for NP_071775.1

    Status: PROVISIONAL

    Source sequence(s)
    X97541
    UniProtKB/Swiss-Prot
    P52632
    UniProtKB/TrEMBL
    A0A0G2JSR4
    Related
    ENSRNOP00000026354.1, ENSRNOT00000026354.3
    Conserved Domains (4) summary
    cd10420
    Location:573717
    SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
    pfam01017
    Location:141330
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:332582
    STAT_bind; STAT protein, DNA binding domain
    pfam02865
    Location:2124
    STAT_int; STAT protein, protein interaction domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    88686207..88712313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    84424576..84451052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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