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Stat3 signal transducer and activator of transcription 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25125, updated on 17-Jan-2022

Summary

Official Symbol
Stat3provided by RGD
Official Full Name
signal transducer and activator of transcription 3provided by RGD
Primary source
RGD:3772
See related
Ensembl:ENSRNOG00000019742
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables CCR5 chemokine receptor binding activity; glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues See more
Orthologs
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Genomic context

See Stat3 in Genome Data Viewer
Location:
10q31
Exon count:
24
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85811206..85863057, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88790401..88842263, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A Neighboring gene U2 spliceosomal RNA Neighboring gene caveolae associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93551

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR5 chemokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leptin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within eye photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in growth hormone receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse to nucleus signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in radial glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to leptin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to leptin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within sexual reproduction ISO
Inferred from Sequence Orthology
more info
 
involved_in sexual reproduction ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within temperature homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in temperature homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
located_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal transducer and activator of transcription 3
Names
signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012747.2NP_036879.1  signal transducer and activator of transcription 3

    See identical proteins and their annotated locations for NP_036879.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087025
    UniProtKB/Swiss-Prot
    P52631
    Related
    ENSRNOP00000026760.3, ENSRNOT00000026760.5
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    85811206..85863057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247259.4XP_006247321.1  signal transducer and activator of transcription 3 isoform X3

    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  2. XM_006247257.4XP_006247319.1  signal transducer and activator of transcription 3 isoform X1

    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  3. XM_006247258.4XP_006247320.1  signal transducer and activator of transcription 3 isoform X2

    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
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