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Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25116, updated on 12-Aug-2018

Summary

Official Symbol
Hsd11b1provided by RGD
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1provided by RGD
Primary source
RGD:2834
See related
Ensembl:ENSRNOG00000005861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00065
Summary
catalyzes the interconversion of cortisol and cortisone; plays a role in glucocorticoid metabolism; may regulate blood pressure [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 1885.5), Kidney (RPKM 1094.3) and 5 other tissues See more
Orthologs

Genomic context

See Hsd11b1 in Genome Data Viewer
Location:
13q27
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111946626..111996536, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (116502230..116551778, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 6 Neighboring gene hypothetical protein LOC100125367 Neighboring gene TRAF3 interacting protein 3 Neighboring gene uncharacterized LOC102547023 Neighboring gene G0/G1switch 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IDA
Inferred from Direct Assay
more info
PubMed 
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
glucocorticoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lung development ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
corticosteroid 11-beta-dehydrogenase isozyme 1
Names
11-DH
11-beta-HSD1
11-beta-hydroxysteroid dehydrogenase 1
11-beta-hydroxysteroid dehydrogenase, type 1
11beta-HSD1
cortocosteroid 11-beta dehydrogenase
hydroxysteroid dehydrogenase, 11 beta type 1
NP_058776.2
XP_006250533.1
XP_006250535.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017080.2NP_058776.2  corticosteroid 11-beta-dehydrogenase isozyme 1

    See identical proteins and their annotated locations for NP_058776.2

    Status: VALIDATED

    Source sequence(s)
    BC078865, CK474613
    UniProtKB/Swiss-Prot
    P16232
    Related
    ENSRNOP00000007870.4, ENSRNOT00000007870.5
    Conserved Domains (2) summary
    cd05332
    Location:28275
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:31217
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    111946626..111996536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250473.3XP_006250535.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

    See identical proteins and their annotated locations for XP_006250535.1

    UniProtKB/Swiss-Prot
    P16232
    Conserved Domains (2) summary
    cd05332
    Location:28275
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:31217
    adh_short; short chain dehydrogenase
  2. XM_006250471.2XP_006250533.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

    Conserved Domains (2) summary
    cd05332
    Location:68315
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:71257
    adh_short; short chain dehydrogenase

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    104178893..104204865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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